The clinical efficacy of Japanese Cayratia Herb combined with mesalazine in the treatment of ulcerative colitis: a randomized controlled clinical trial
- Conditions
- ulcerative colitisJapanese Cayratia Herb (Cayratia japonica (Thunb.) Gagnep)mesalazineUlcerative colitisRandomized controlled trial
- Registration Number
- TCTR20230913006
- Lead Sponsor
- ijiang Ji
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 94
(1) Meet the above diagnostic criteria and syndrome differentiation criteria;
(2) No history of diarrhea or other gastrointestinal diseases in the past 4 weeks;
(3) No antibiotics and microecologics in the past 1 month;
(4) Patients voluntarily joined this study and signed informed consent.
(1) Combined with severe complications of UC, such as local stenosis, intestinal obstruction, intestinal perforation, rectal rest, toxic colon dilatation, colon cancer, rectal cancer and anal disease;
(2) Pregnant or preparing for pregnancy, lactating women;
(3) Allergic constitution and multiple drug allergies;
(4) Combined with liver, kidney, hematopoietic system, endocrine system and other serious diseases and malignant tumors;
(5) Researchers who have participated in or are participating in other trials within the past 1 month;
(6) Patients with mental disorders.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method lcerative colitis activity score Before treatment,After treatment which included defecation frequency, hematochezia, endoscopic findings, and overall rating of physicians, with lower scores having lower activity.
- Secondary Outcome Measures
Name Time Method Total effective rate After treatment Complete remission, effective, ineffective,Laboratory indexes Before treatment,After treatment interleukin-6, interleukin-12, interleukin-10, transforming growth factor