The Monocyte Subsets in Obese Patients With and Without Metabolic Syndrome

• Conditions: Obesity; Metabolic Syndrome

• Registration Number: NCT03241394
• Lead Sponsor: University Hospital, Ioannina

Brief Summary

Obesity is associated with a chronic low-grade inflammation characterized by macrophage infiltration in adipose tissue that induces insulin resistance and the appearance of metabolic syndrome (MS). The aim of the study was the investigation of whether circulating monocyte subsets are differentially regulated in MS.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-07-25
• Status Verified: 2017-08
• Study First Submitted: 2017-08-02
• Study First Submitted QC: 2017-08-02
• Last Update Submitted: 2017-08-02
• Study First Posted: 2017-08-07
• Last Update Posted: 2017-08-07
• Primary Completion: 2017-09-15
• Study Completion: 2017-09-15

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Exclusion Criteria

Age less than 18 years old, pregnancy, breast feeding, kidney disease, liver disease, gastrointestinal disease, malignancy, any endocrine disorder or metabolic disease, other than obesity or type 2 diabetes mellitus (T2DM), alteration of body weight (BW) by up of 5% of the initial BW during the last 3 months, any state of stress or systemic inflammation and taking any of the following drugs, within 3 weeks prior to the start of the study: hypolipidemic agents, antidiabetics, drugs for weight loss, nonsteroidal antiinflammatory drugs, glucocorticoids.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Monocyte subsets	Baseline measurement	Absolute blood count of classical (Mon1A), intermediate (Mon2A) and nonclassical (Mon3A) monocyte subsets wil be measured by flow cytometry.

Trial Locations

Locations (1)

University Hospital of Ioannina; 🇬🇷 Ioánnina, Greece