The relationship of inflammation in adipose tissue and inflammation in blood in patients with morbid obesity and patients with significant weight loss after bariatric surgery.
Recruiting
- Conditions
- Morbid obesityType 2 diabetesCardiovascular diseaseVitamin D deficiencyMorbide obesitasDiabetes mellitus type 2Hart- en vaatziektenVitamine D deficiëntie
- Registration Number
- NL-OMON28337
- Lead Sponsor
- Sint Franciscus Vlietland Gasthuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 200
Inclusion Criteria
Scheduled for bariatric surgery, which means BMI > 40 kg/m2 or BMI >35 kg/m2 and obesity related comorbidity.
Ages 18 or above
Exclusion Criteria
Previous cholecystectomy
Acute inflammatory disease 6 weeks prior to surgery
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate the effect of bariatric surgery induced weight loss on the relationship between C3 and vitamin D in visceral and subcutaneous adipose tissue and serum.
- Secondary Outcome Measures
Name Time Method To analyze the relationship between concentrations of C3 and vitamin D in visceral and subcutaneous adipose tissue and serum in morbidly obese subjects scheduled for bariatric surgery<br /><br>To analyze the relation of vitamin D and C3 with general markers of inflammation and classic cardiovascular risk factors in morbidly obese subjects scheduled for bariatric surgery<br /><br>To evaluate the effect of weight loss, due to bariatric surgery, on the relation of vitamin D and C3 with general markers of inflammation and classic cardiovascular risk factors<br>To evaluate the effect of different bariatric procedures on C3 and vitamin D in visceral and subcutaneous adipose tissue and serum<br /><br>To investigate acute changes (day 1 and day 7 postoperatively) in serum C3 levels in both non-obese and (morbid) obese subjects