Adipose Tissue Inflammation in Individuals Undergoing Bariatric Surgery

Completed

• Conditions: Bariatric Surgery Candidate; Obesity, Morbid

• Registration Number: NCT03419273
• Lead Sponsor: University of Missouri-Columbia

Brief Summary

A growing body of work done over the past few decades has established that adipose tissue as an active endocrine organ which secretes a wide range of metabolic and immunological factors collectively called "adipokines (1)." Importantly, these secreted factors enter into the circulation and have paracrine and autocrine actions, which profoundly impact systemic metabolism (e.g., insulin sensitivity). Additionally, in animals, loss of ovarian hormone production via ovariectomy (similar to menopause in humans) leads to increases in both in adipose tissue mass and in adipose tissue inflammation (2) making this tissue less healthy than that from premenopausal animals. To date, no studies have investigated the effect of menopause on abdominal fat in overweight individuals. Knowing if adipose tissue-specific changes occur with menopause may potentially lead to recommendations or therapeutics to improve women's health post menopause.

Detailed Description

Subjects will just have to agree to having a small amount of adipose tissue being removed during the bariatric surgery. The investigators will also collect a blood sample at that time. There will be no other visits for the subject.

Study Timeline

• Study Start: 2017-07-01
• Study First Submitted: 2018-01-20
• Study First Submitted QC: 2018-01-25
• Study First Posted: 2018-02-01
• Primary Completion: 2019-03-31
• Study Completion: 2019-07-01
• Status Verified: 2019-10
• Last Update Submitted: 2019-10-01
• Last Update Posted: 2019-10-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 84

Inclusion Criteria

• Women who are premenopausal or who are postmenopausal and have been for at least one year.

Males will be recruited to age match female subjects. All subject are already scheduled to have bariatric surgery at the University of Missouri-Columbia Department of Surgery.

Exclusion Criteria

• Women who are perimenopausal. Women who are on Hormone Replacement Therapy.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
macrophage	measured in the one sample collected at surgery	macrophage
Il-6	measured in the one sample collected at surgery	Il-6
TNFa	measured in the one sample collected at surgery	TNFa

Trial Locations

Locations (1)

University of Missouri; 🇺🇸 Columbia, Missouri, United States