Nantes Bariatric Surgery Cohort

Not Applicable

Not yet recruiting

• Conditions: Obesity
• Interventions: Other: Nantes bariatric surgery cohort

• Registration Number: NCT06625762
• Lead Sponsor: Nantes University Hospital

Brief Summary

While current research suggests that inflammation of adipose tissue in obesity is linked to accelerated aging, it has yet to be determined in humans how this could enhance preventative and personalized medicine for obese individuals. The NBC study aims to investigate :

1. Whether bariatric surgery is associated with changes in biological age

2. If bariatric surgery alters adipocyte dysfunction, the microbiota and biological rhythms

3. Whether changes in adipocyte dysfunction, microbiota and biological rhythms are linked to changes in biological age.

To achieve this, establishing a biocollection before, during and after bariatric surgery will be crucial in addressing these questions

Detailed Description

The study of the Nantes Bariatric Surgery Cohort (NBC) aims to evaluate the impact of bariatric surgery on biological age, adipocyte dysfunction, microbiota, and biological rhythms in individuals with obesity. This observational study will include 300 participants over 3.5 years. It involves pre-operative, peri-operative, and post-operative visits to collect clinical, biological, and lifestyle data. Key assessments include anthropometrics, blood tests, questionnaires, and biocollections

Study Timeline

• Status Verified: 2024-06
• Study First Submitted: 2024-09-03
• Study First Submitted QC: 2024-10-01
• Study First Posted: 2024-10-03
• Last Update Submitted: 2024-11-28
• Last Update Posted: 2024-12-02
• Study Start: 2025-03-01
• Primary Completion: 2027-03-01
• Study Completion: 2028-03-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
observation of the change in biological age after bariatric surgery	Nantes bariatric surgery cohort	Patients over 18 years of age suffering from obesity and requiring bariatric surgery. Evolution of biological age 1 year after surgery, defined by the difference between age biological at TPO and TAC 1 year, estimated by measuring the phenotypic age, itself determined from the following eight variables: albumin; creatinine; fasting blood sugar; CRP ; lymphocyte count; mean corpuscular volume of red blood cells; Anisocytosis index of red blood cells; alkaline phosphatases; leukocyte rate.

Primary Outcome Measures

Name	Time	Method
Observe how biological age evolves between pre-bariatric surgery and 1 year after bariatric surgery	1 year	Biological age will be estimated by measuring phenotypic age. The phenotypic age will be determined from the following variable: albumin, creatinine, fasting glucose, CRP, lymphocyte count, red cell size, alkaline phosphates, leukocyte count.

Trial Locations

Locations (1)

Nantes University Hospital; 🇫🇷 Nantes, Loire-Atlantique, France