To Check if chewing piper betel leaf along with arecanut from copper based fungicide treated and untreated arecanut palms can lessen the salivay and serum copper levels.

Phase 4

• Conditions: Health Condition 1: Z00-Z99- Factors influencing health status and contact with health services

• Registration Number: CTRI/2024/08/071957
• Lead Sponsor: Dr Soma Susan Varghese

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

Individuals habitually chewing areca nut and arecanut products and are willing to participate in the study.

Exclusion Criteria

Individuals with history of any other systemic illness.Individuals with the history of medication. Individuals with any salivary gland pathology .Individuals using copper vessels for diet and water intakeIndividuals working with fertilizers.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Chewing raw areca nut from copper based fungicide untreated palms along with piper betel leaf decrease salivary copper levels due to the protective and chelating property of betel leaf flavonoids. <br/ ><br> <br/ ><br>Timepoint: 2 weeks <br/ ><br>

Secondary Outcome Measures

Name	Time	Method
High copper content in areca nuts from copper-based fungicide-treated plantations, compared to untreated ones, potentially leads to elevated salivary copper levels upon chewing and contributes to the development of oral submucous fibrosis (OSF) and oral squamous cell carcinoma. <br/ ><br> <br/ ><br> <br/ ><br>Commercially available areca nut products, which commonly lack betel leaf, can lead to increased risk of OSMF and oral squamous cell carcinoma due to their inclusion of tobacco.It is hypothesized that chewing raw areca nut from copper based fungicide untreated palms along with piper betel leaf may decrease salivary copper levels due to the protective and chelating property of betel leaf flavonoids.this can decrease the incidence of oral submucous fibrosis and oral squamous cell carcinoma <br/ ><br> <br/ ><br>Timepoint: 6 months of intervention and stoppage of usage of commercial arecanut and copper fungicide treated arecanuts