Behavioral Economic Analysis of Demand for Marijuana
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 133
- 试验地点
- 1
- 主要终点
- Validity of the Marijuana Purchase Task (MPT)
研究概览
简要总结
This laboratory study will employ a multi-session experimental design to examine the behavioral economic demand for marijuana, by studying effect of marijuana administration (High THC) on demand for marijuana, and marijuana smoking topography. The study will recruit 100 non-treatment seeking marijuana users who smoke marijuana at least twice weekly.
详细描述
This laboratory study will employ a multi-session experimental design to examine craving for marijuana, the effect of marijuana administration (High THC) on behavioral economic demand for marijuana, and marijuana smoking topography. The study will recruit 100 non-treatment seeking marijuana users who smoke marijuana at least twice weekly. The relationship between hypothetical and actual demand for marijuana will be examined. We will also investigate relationship between demand for marijuana and indices of marijuana smoking topography. The study will recruit 100 non-treatment seeking marijuana users who smoke marijuana at least twice weekly to obtain a final sample of 85 with complete data (15% of attrition). Participants will be tested at a baseline session and during two experimental sessions (an ad libitum marijuana smoking session and a marijuana smoking topography session). This study will confirm the utility of the hypothetical marijuana purchase task as a reliable and valid tool for assessing behavioral economic marijuana demand.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •marijuana use at least 8 times in the past month on average and at least monthly for the past 6 months
- •English-speaking
- •negative urine toxicology screen for drugs other than marijuana
- •non-treatment seeking
- •purchase of marijuana at least twice in the past 6 months to confirm familiarity with the construct to be measured
排除标准
- •positive pregnancy test
- •inability to use contraception during the study
- •poor physical health
- •positive breath alcohol concentration
- •diagnosis of a current affective disorder, psychosis, and panic disorder
- •self-report of past serious adverse reaction to marijuana
- •current psychotropic drug use
- •smoking more than 20 tobacco cigarettes per day
- •inability to abstain from marijuana for 15 hours
- •body mass index outside 18.5-30 kg/m2 range
研究组 & 干预措施
High THC dose (6% THC)
Smoked marijuana cigarettes (High THC dose [6% THC])
干预措施: Smoked marijuana cigarettes: High THC dose (6% THC) (Drug)
结局指标
主要结局
Validity of the Marijuana Purchase Task (MPT)
时间窗: Duration of the experimental session (i.e., 60 minutes)
The Marijuana Purchase Task will be used to collect data on marijuana demand. Participants indicate how much marijuana they would purchase at varying levels of price (e.g., free - $60). Indices of marijuana demand are derived from the task and used to determine the relative value of marijuana for each participant. Hits purchased on the MPT will correspond with actual number of hits purchased and smoked in the laboratory. Primary outcome is percentage of participants who purchased and smoked exactly what they said they would.
次要结局
- Change in Marijuana Craving Questionnaire (MCQ)(The MCQ will be administered pre- and post- marijuana smoking during the experimental session, up to 6 hours)
- Marijuana Smoking Topography(Marijuana smoking topography indices will be collected during the 1-hour ad libitum marijuana smoking topography experimental session.)
研究者
Elizabeth Aston
Assistant Professor
Brown University