Comparison of effect of atropine drops and Amitriptyline tablet in clozapine-induced hypersalivatio
- Conditions
- Schizophrenia.Schizophrenia
- Registration Number
- IRCT201701136691N3
- Lead Sponsor
- Mazandaran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 40
Every hospitalized patient taking Clozapine and recieved diagnosis of Schizophrenia, Schizoaffective or other psychiatric disorders according to DSM-IV ; Age between 18-65 year old ; Having nacturnal sialorrhea more than 2 scores based on TNHS ; Agreement and optional participation of patients is necessary.
Exclusion criteria: Sensitivity to Atropine and Amitriptyline ; Comorbidity with other diseases produce sialorrhea like Parkinson dx and Cerebral palsy ;Affliction with untreated constipation, Bladder outlet obsrtuction and urinary retention; Co-consumption of anticholinergic drugs ; Lactation &Pregnancy ; past positive history of myasthenia gravis, Cardiac arrythmia, Glucoma, Pyloric obsrtruction,Paralytic ileus, Prostatic hypertrophia and Renal dysfunction ; Sever dysoutonomy 8. Mental retardation 9. Bipolar schizoaffective and Bipolar mood disorder
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Severity and Frequency of sialorhea. Timepoint: Daily in first week and then weekly until4 weeks. Method of measurement: Toronto Nacturnal Hypersalivation Scale,Drooling scale.
- Secondary Outcome Measures
Name Time Method Palpitation. Timepoint: Baseline and weeks 1-2-3-4 after begining of treatment. Method of measurement: puise rate measuring at Baseline and weeks 1-2-3-4 after begining of treatment.;Hypertension. Timepoint: Baseline and weeks 1-2-3-4 after begining of treatment. Method of measurement: Blood pressure measuring at Baseline and weeks 1-2-3-4 after begining of treatment.