Prevention of rejection after transplantation by donor-specific suppression immunity with donor exosomes (protocol id: DOBEX)

• Conditions: liver grafts; rejection; 10019654

• Registration Number: NL-OMON41041
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

The experimental group of patients that undergo liver transplantation in Erasmus MC

Exclusion Criteria

Liver transplant recipients who recieve a donor liver of which we do not obtain donor spleen tissue
Liver transplant recipients with a low white blood cell count (<4x10E6 cells/ml) at 1 week after transplantation

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>induction of apoptosis in donor-specific T-cells that response directly to<br /><br>allo-antigen, and induction of anergy (= unresponsiveness to antigenic<br /><br>stimulation) in donor specific T-cells that respond to indirectly presented<br /><br>allo-antigens.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>n.a.</p><br>