Acute Effect of Exercise on Vascular Function

Completed

• Conditions: Aging
• Interventions: Other: Moderate-paced walking; Other: Slow-paced walking; Other: Interval Training; Device: Treadmill

• Registration Number: NCT02408614
• Lead Sponsor: University of Florida

Brief Summary

The study objectives are the following: 1) To examine the acute vascular responses to continuous low- and moderate-intensity exercise and interval training; and 2) To examine the influence of age and gender on these responses.

Detailed Description

The type, intensity and duration of exercise, fitness state, and timing of measurements have been reported to influence the acute vascular responses to exercise. However, little is known regarding the influence of interval training, aging and gender on these responses. The objectives of this study are: 1) to examine the acute vascular responses to continuous low- and moderate-intensity exercise and interval training; and 2) to examine the influence of age and gender on these responses. Subjects will perform the following 3 types of treadmill exercise in a random order: 1) slow-pace walking; 2) moderate-pace walking; and 3) interval training. Flow mediated dilation using high resolution ultrasonography and arterial stiffness using applanation tonometry will be measured before, immediately after and 1-hour after each acute bout of exercise.

Study Timeline

• Study First Submitted: 2015-03-31
• Study First Submitted QC: 2015-04-02
• Study First Posted: 2015-04-03
• Study Start: 2015-06
• Status Verified: 2019-01
• Primary Completion: 2019-01-23
• Study Completion: 2019-01-23
• Last Update Submitted: 2019-01-23
• Last Update Posted: 2019-01-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 69

Inclusion Criteria

• Men and women 18 to 79 years of age
• Women will be premenopausal or postmenopausal (either natural or surgical) defined as a cessation of menses for at least 2 years.
• Premenopausal women will be eumenorrheic.
• Able to give consent.

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Exclusion Criteria

• History of hepatic disease or infection with hepatitis B, C or HIV
• History of other relevant on-going or recurrent illness
• Recent (within 3 months) or recurrent hospitalizations
• Current intake of medications that may affect study results
• Use of tobacco products
• Premenopausal women taking oral contraceptives and postmenopausal women taking hormone replacement therapy.
• Pregnancy (positive urine pregnancy test) or lactation
• Perimenopausal women

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Moderate-paced walking	Moderate-paced walking	Subjects will complete 47 minutes of walking at a moderate pace.
Interval training	Treadmill	Subjects will complete 40 minutes of walking alternating between a moderate and fast pace.
Slow-paced walking	Slow-paced walking	Subjects will complete 47 minutes of walking at slow pace.
Moderate-paced walking	Treadmill	Subjects will complete 47 minutes of walking at a moderate pace.
Slow-paced walking	Treadmill	Subjects will complete 47 minutes of walking at slow pace.
Interval training	Interval Training	Subjects will complete 40 minutes of walking alternating between a moderate and fast pace.

Primary Outcome Measures

Name	Time	Method
Change in vascular endothelial function	Baseline, 15 minutes after exercise and 1 hour after exercise	Brachial artery endothelium-dependent flow-mediated dilation to reactive hyperemia will be measured using high resolution ultrasonography. Brachial artery diameter and blood velocity will be measured before and after occluding the forearm for 5 minutes by inflating a cuff to 250 mmHg.

Secondary Outcome Measures

Name	Time	Method
Change in arterial stiffness	Baseline, 15 minutes after exercise and 1 hour after exercise	Arterial stiffness (aortic pulse wave velocity and augmentation index) will be measured using applanation tonometry.

Trial Locations

Locations (1)

Integrative Cardiovascular Physiology Laboratory; 🇺🇸 Gainesville, Florida, United States