Acute Effect of Exercise on Vascular Function
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 69
- 试验地点
- 1
- 主要终点
- Change in vascular endothelial function
研究概览
简要总结
The study objectives are the following: 1) To examine the acute vascular responses to continuous low- and moderate-intensity exercise and interval training; and 2) To examine the influence of age and gender on these responses.
详细描述
The type, intensity and duration of exercise, fitness state, and timing of measurements have been reported to influence the acute vascular responses to exercise. However, little is known regarding the influence of interval training, aging and gender on these responses. The objectives of this study are: 1) to examine the acute vascular responses to continuous low- and moderate-intensity exercise and interval training; and 2) to examine the influence of age and gender on these responses. Subjects will perform the following 3 types of treadmill exercise in a random order: 1) slow-pace walking; 2) moderate-pace walking; and 3) interval training. Flow mediated dilation using high resolution ultrasonography and arterial stiffness using applanation tonometry will be measured before, immediately after and 1-hour after each acute bout of exercise.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 79 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and women 18 to 79 years of age
- •Women will be premenopausal or postmenopausal (either natural or surgical) defined as a cessation of menses for at least 2 years.
- •Premenopausal women will be eumenorrheic.
- •Able to give consent.
排除标准
- •History of hepatic disease or infection with hepatitis B, C or HIV
- •History of other relevant on-going or recurrent illness
- •Recent (within 3 months) or recurrent hospitalizations
- •Current intake of medications that may affect study results
- •Use of tobacco products
- •Premenopausal women taking oral contraceptives and postmenopausal women taking hormone replacement therapy.
- •Pregnancy (positive urine pregnancy test) or lactation
- •Perimenopausal women
结局指标
主要结局
Change in vascular endothelial function
时间窗: Baseline, 15 minutes after exercise and 1 hour after exercise
Brachial artery endothelium-dependent flow-mediated dilation to reactive hyperemia will be measured using high resolution ultrasonography. Brachial artery diameter and blood velocity will be measured before and after occluding the forearm for 5 minutes by inflating a cuff to 250 mmHg.
次要结局
- Change in arterial stiffness(Baseline, 15 minutes after exercise and 1 hour after exercise)