Acute Vascular Response to Exercise in Women With Nonobstructive Coronary Artery Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 7
- 试验地点
- 2
- 主要终点
- Change in endothelium-dependent dilation
研究概览
简要总结
The purpose of this study is to examine the acute effect of exercise on vascular function in women with nonobstructive coronary artery disease.
详细描述
Women are more likely to have nonobstructive coronary artery disease (CAD) . The purpose of this study is to examine the acute effect of exercise on vascular function in women with nonobstructive coronary artery disease. Endothelium-dependent and -independent dilation, arterial stiffness and wave reflection will be measured at baseline and after walking on a treadmill at a slow pace for 47 minutes. Endothelium-dependent dilation will be measured using brachial artery flow-mediated dilation via high resolution ultrasonography. Endothelium-independent dilation will be measured using brachial artery dilation to sublingual nitroglycerin. Arterial stiffness and wave reflection will measured using applanation tonometry.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 89 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •women with non-obstructive coronary artery disease documented within the past 5 years by coronary angiogram as no coronary arteries with stenosis greater than 50% lesions
- •age 18 to 89 years
- •able to complete maximal graded exercise test
排除标准
- •use of tobacco products within the previous six months
- •use of oral contraceptives or hormone replacement therapy within the prior year
- •pregnancy (positive urine pregnancy test) or lactation
- •history of hepatic disease or infection with hepatitis B, C or HIV
结局指标
主要结局
Change in endothelium-dependent dilation
时间窗: Baseline, 15 minutes after exercise and 1 hour after exercise
Brachial artery endothelium-dependent flow-mediated dilation to reactive hyperemia will be measured using high resolution ultrasonography. To determine flow-mediated dilation, brachial artery diameter and blood velocity will be measured before and after occluding the forearm for 5 minutes by inflating a cuff to 250 mmHg.
次要结局
- Change in endothelium-independent dilation(Baseline, 15 minutes after exercise)
- Change in arterial stiffness and wave reflection(Baseline, 15 minutes after exercise and 1 hour after exercise)