Acute Vascular Response to Exercise in Women With Nonobstructive Coronary Artery Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Nonobstructive Coronary Artery Disease
- Sponsor
- University of Florida
- Enrollment
- 7
- Locations
- 1
- Primary Endpoint
- Change in endothelium-dependent dilation
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The purpose of this study is to examine the acute effect of exercise on vascular function in women with nonobstructive coronary artery disease.
Detailed Description
Women are more likely to have nonobstructive coronary artery disease (CAD) . The purpose of this study is to examine the acute effect of exercise on vascular function in women with nonobstructive coronary artery disease. Endothelium-dependent and -independent dilation, arterial stiffness and wave reflection will be measured at baseline and after walking on a treadmill at a slow pace for 47 minutes. Endothelium-dependent dilation will be measured using brachial artery flow-mediated dilation via high resolution ultrasonography. Endothelium-independent dilation will be measured using brachial artery dilation to sublingual nitroglycerin. Arterial stiffness and wave reflection will measured using applanation tonometry.
Investigators
Eligibility Criteria
Inclusion Criteria
- •women with non-obstructive coronary artery disease documented within the past 5 years by coronary angiogram as no coronary arteries with stenosis greater than 50% lesions
- •age 18 to 89 years
- •able to complete maximal graded exercise test
Exclusion Criteria
- •use of tobacco products within the previous six months
- •use of oral contraceptives or hormone replacement therapy within the prior year
- •pregnancy (positive urine pregnancy test) or lactation
- •history of hepatic disease or infection with hepatitis B, C or HIV
Outcomes
Primary Outcomes
Change in endothelium-dependent dilation
Time Frame: Baseline, 15 minutes after exercise and 1 hour after exercise
Brachial artery endothelium-dependent flow-mediated dilation to reactive hyperemia will be measured using high resolution ultrasonography. To determine flow-mediated dilation, brachial artery diameter and blood velocity will be measured before and after occluding the forearm for 5 minutes by inflating a cuff to 250 mmHg.
Secondary Outcomes
- Change in endothelium-independent dilation(Baseline, 15 minutes after exercise)
- Change in arterial stiffness and wave reflection(Baseline, 15 minutes after exercise and 1 hour after exercise)