Comparison of Topical Analgesic With Saline Rinses in Post Extraction Healing Among Hypertensive and Non-hypertensive Subjects
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 66
- 主要终点
- Number of participants with unhealed extraction socket
研究概览
简要总结
The aim of this study is to determine the beneficial effect of mouth rinses, both topical analgesic and saline regimens as an adjuvant therapy in the presence of standard prescription of post-operative pain killers on the progress of socket healing following routine dental extraction.
详细描述
Hypertension is a highly prevalent cardiovascular disease, which affects over 1 billion people worldwide. It varies with age, race, education and so forth.1 The National Health Survey of Pakistan estimated that hypertension affects 18% of adults and 33% of adults are above 45 years old.2It is a common disease encountered in dental setting. Its wide spreading, terrible consequences, and life-long treatment require an attentive approach by dentists. Knowledge of hypertension is important for dentists especially for risk assessment for dental treatment. This may lead to improved monitoring and treatment.
Dental treatment in hypertensive patients necessitates special attention, because any stressful procedure may increase blood pressure and trigger acute complications such as cardiac arrest or stroke. Extractions are usually done for teeth which are not salvageable. Dentists routinely advice use of warm saline rinses to help in healing of post extraction socket. But for hypertensive patients this recommendation is potentially harmful There is no evidence based guidelines on using saline rinses for post extraction oral care among hypertensives. Moreover, advantage of orally dissolved topical analgesics in addition to orally administered analgesic is questionable.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 80 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy subjects requiring simple tooth extraction (elevator or forceps) which were either known cases of controlled hypertension under medical treatment or confirmed non hypertensives.
排除标准
- •Subjects requiring surgical tooth extraction involving bone removal and suturing, uncontrolled systemic disorders (diabetes mellitus, hypertension, blood coagulopathies, metabolic bone disorders), on platelet aggregation therapy or warfarin (anticoagulants) or bisphosphonate therapy.
研究组 & 干预措施
Group 1
Non hypertensive Intervention: On analgesic mouth rinses (dissolved Aspirin)
干预措施: analgesic mouth rinses (dissolved Aspirin) (Drug)
Group 2
Hypertensive Intervention: On analgesic mouth rinses (dissolved Aspirin)
干预措施: analgesic mouth rinses (dissolved Aspirin) (Drug)
Group 3
Non Hypertensive Intervention: On normal saline rinses.
干预措施: Normal saline rinses. (Drug)
结局指标
主要结局
Number of participants with unhealed extraction socket
时间窗: Number of participants with unhealed extraction socket at 7th day
次要结局
未报告次要终点
研究者
Rabia Ali
Dr. Rabia Ali
Aga Khan University
