Imaging Radiotherapy-induced brain injury using advanced MRI and PET, a pilot

Recruiting

• Conditions: brain injury after radiotherapy; 10007963

• Registration Number: NL-OMON54488
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

- adults (>18 years),
- referred for treatment of tumours located in nasopharynx, parotids,
oropharynx, skull base and sinonasal cavity (under which meningioma, pituitary,
chondrosarcoma, chondroma) with radiotherapy (photons or protons), with or
without systemic treatment, with a close proximity of 2 cm of the clinical
target volume (CTV elective dose) to the brain or brainstem.

Exclusion Criteria

- age <18 years old at baseline;
- brain neurological disease other than consequences of head and neck cancer
and its treatment (like a stroke);
- history of psychiatric disease;
- history of chemotherapy or radiotherapy for other tumours;
- chronic treatment with verapamil at baseline;
- pregnancy;
- contradictions for performing MRI, such as non-MRI compatible heart
pacemaker, metallic foreign body in the eye, aneurysm clip in the brain or
claustrophobic patient;
- contrast allergies.
- Tumour extension into the brain

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified