Utility of Renal Biomarkers in Cirrhosis
Completed
- Conditions
- CirrhosisAscitis
- Registration Number
- NCT01217983
- Lead Sponsor
- University Hospital, Geneva
- Brief Summary
Evaluation of kidney function is critical in cirrhotic patients as there is a clear relationship between renal failure and prognosis. The investigators hypothesized that in this population new biomarkers of renal function could help in early detection of acute renal failure and in discrimination between renal and pre-renal causes. Finally the investigators hypothesized that such biomarkers could predict short-term outcome in this population.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 105
Inclusion Criteria
- Age ≥ 18 years
- Known or suspected cirrhosis
- Suspected ascitis
- Informed consent signed
Exclusion Criteria
- Proven multifocal hepatocellular carcinoma
- Acute gastric hemorrhage (active or < 2 weeks)
- Known end-stage renal disease or on dialysis before admission
- Recipients of kidney or liver transplants
- Transferred from another institution
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Early detection of acute kidney injury in hospitalized cirrhotic patients with ascitis using new renal biomarkers 30 days Acute kidney injury will be defined using RIFLE and AKIN criteria.
- Secondary Outcome Measures
Name Time Method Prediction of adverse clinical outcomes (Renal replacement therapy, transfer to ICU, all cause mortality). 30 days Prediction of AKI developement using renal artery resistive indexes. 30 days Discrimination between different type of AKI. 30 days
Trial Locations
- Locations (1)
University Hospital of Geneva
🇨🇭Geneva, Switzerland