Kidney Biomarkers of Acute Kidney Injury in Patients With Knee Arthroplasty

Completed

• Conditions: Acute Kidney Injury; Arthroplasty, Replacement, Knee

• Registration Number: NCT02642731
• Lead Sponsor: Kuopio University Hospital

Brief Summary

Sensitive renal markers have been studied abundantly in connection with open heart, liver and transplantation surgery; however in major orthopaedic surgery their use is anecdotal. The aim of the present study is to evaluate use of sensitive renal markers, NGAL (Neutrophil gelatinase associated lipocalin ), KIM-1 (Kidney injury molecule- 1), LFABP (liver-type fatty acid-binding protein), and IL-18 (interleukin -18), in patients coming for elective TKA (total knee arthroplasty) as a pilot study before large study concerning acute kidney injury in orthopaedic surgery.

Detailed Description

Acute renal deterioration is a serious adverse event in elective surgery. Serum creatinine based diagnostics of acute kidney injury may delay diagnosis and produce false negative results since serum creatinine is affected by diet, muscle mass, used hydration therapy. In recent times new markers have been developed and tested in order to find sensitive, fast and reliable marker of renal deterioration.

Study Timeline

• Study Start: 2013-09
• Primary Completion: 2015-12
• Study Completion: 2015-12
• Study First Submitted: 2015-12-25
• Study First Submitted QC: 2015-12-25
• Study First Posted: 2015-12-30
• Status Verified: 2018-02
• Last Update Submitted: 2018-02-25
• Last Update Posted: 2018-02-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• informed consent
• allergy to NSAIDs

Exclusion Criteria

• no informed consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Renal function	time zero hours to 48 hours	S-creatinine, Cystatin C, estimated GFR

Secondary Outcome Measures

Name	Time	Method
Concentraton of sensitive renal markers	time zero hours to 24 hours	U-NGAL, P-NGAL, U-KIM-1, U-IL-18

Trial Locations

Locations (1)

Kuopio University Hospital; 🇫🇮 Kuopio, Northern Savo, Finland