Prevention of Acute Kidney Injury Through Biomarker-guided Nephrological Intervention
- Conditions
- Acute Kidney Injury
- Interventions
- Other: Early nephrologist consultation
- Registration Number
- NCT02730637
- Lead Sponsor
- Robert Bosch Medical Center
- Brief Summary
This study examines the clinical relevance of early biomarkers to detect and prevent acute kidney injury. High-risk patients for developing acute kidney injury will be screened at initial presentation (emergency department and intensive care unit) for TIMP2xIGFBP7. In case of elevated readings patients will be randomized in two arms: The control group will be treated with standard care, the intervention group will receive an early nephrologic consultation.
- Detailed Description
This study examines the impact of an early biomarker-guided intervention on the development of acute kidney injury (AKI). New biomarkers indicate kidney damage in an early stage before developing acute kidney injury according to AKI Kidney Disease Improving Global Outcomes (KDIGO) Definition is detectable. The investigators want to test if it's possible to prevent AKI based on elevated urinary biomarkers. Eligible patients will be randomly assigned to two groups, a control and an intervention Group by an early nephrologic consultation. The interventional group will receive an early preventive nephrologist consultation additionally to standard care.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
- no acute kidney injury stage II-III (according to AKI KDIGO definition)
- urinary biomarker levels above cut-off
- inpatient treatment
- age ≥18 years
- informed consent or presumed will
- existing acute kidney injury stage II-III (according to AKI KDIGO definition)
- age < 18 years
- end stage renal disease (ESRD), existing renal replacement therapy
- pregnancy
- withdrawal of consent
- missing presumed will
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Interventional care Early nephrologist consultation Patients in the interventional population receive an early nephrologist consultation which deliberates with attending doctor on preventing measures according to AKI-KDIGO recommendations.
- Primary Outcome Measures
Name Time Method Incidence of AKI in both groups according to AKI KDIGO definition within 24 hours
- Secondary Outcome Measures
Name Time Method Length of hospital stay within 60 days Death within 60 days Severity of AKI in both groups according to AKI KDIGO definition within 60 days Need for renal replacement therapy within 60 days Severety of AKI in both groups according to AKI KDIGO definition within 72 hours Incidence of AKI in both groups according to AKI KDIGO definition within 60 days
Trial Locations
- Locations (1)
Robert-Bosch Hospital
🇩🇪Stuttgart, Germany