NCT00855127撤回不适用
Early Biomarkers of Acute Kidney Injury in Liver Transplant Patients
适应症
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 2
- 主要终点
- Development of acute kidney injury as defined by a 50% increase in serum creatinine
研究概览
简要总结
The purpose of this study is to find new blood and urine tests that detect acute kidney injury earlier than our current blood tests in patients receiving a liver transplant.
详细描述
Patients with end stage liver disease that receive a liver transplant will be studied to determine if novel serum and urine biomarkers (serum cystatin C, urine interleukin-18 [IL-18] and urine neutrophil gelatinase associated lipocalin [NGAL]) can predict the outcome measures listed above.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •First time liver transplant recipient
- •Cadaveric or living donor livers
排除标准
- •Unconscious patients or patients who cannot give consent
- •Pregnant women
- •Prisoners
- •Patients receiving dialysis before or during liver transplant operation
- •Patients receiving simultaneous liver-kidney transplants
结局指标
主要结局
Development of acute kidney injury as defined by a 50% increase in serum creatinine
时间窗: Within 2 to 5 days of liver transplant that is sustained for at least 24 hours
次要结局
- The need for renal replacement therapy(After liver transplant operation to discharge)
- Development of severe acute kidney injury, as defined as a doubling of serum creatinine(Within 2-5 days of transplant that is sustained for at least 24 hours)
- All cause mortality(After liver transplant operation to discharge)
研究者
研究点 (2)
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