New Methods for Early Detection of Acute Kidney Injury After Heart Surgery
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 入组人数
- 200
- 主要终点
- Acute Kidney Injury
研究概览
简要总结
The investigators intend to study 2 new methods for the early detection of Acute Kidney Injury (AKI) after cardiac surgery and compare and combine the predictive abilities of these methods with established renal injury markers and epidemiological models to detect (AKI).
详细描述
Acute Kidney Injury is common after Cardiac surgery and occurs in up to 20% of patients (Ref Rydén).
This study will evaluate two new methods for the early detection of acute kidney injury in 200 patients undergoing elective cardiac surgery at the Karolinska Hospital.
These methods are:
- Ultrasound based measurement of the kidneys blood flow profile measured using renal resistive index (RRI). This will be measured prior and within 4 hours post surgery. Ref Herzberg, Le Dorze.
- Urine creatinine clearance will be measured in the first four hours after cardiac surgery.
The investigators will also measure known renal injury markers in blood and urine samples post operatively. These include Neutrophil gelatinise-associated lipocalin (NGAL), tissue inhibitor of metalloproteinases (TIMP-2), Insulin-like growth factor-binding protein 7 (IGFBP7), Kidney Injury Molecule 1 (KIM-1), Nephroclear, Interleukin 18 (IL-18), Fatty acid-binding protein (L-FABP), Fibulin-1, cystatin C och albumin.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18 years and older
- •Undergoing elective cardiac surgery (Coronary artery bypass grafting, valve surgery, aortic surgery or a combination).
- •Able to understand and give written consent to partake in the study
排除标准
- •Unable to give consent
- •Previously received a renal transplant
- •Renal failure requiring dialysis prior to surgery
- •Persistent atrial fibrillation
结局指标
主要结局
Acute Kidney Injury
时间窗: 48 hours
Acute Kidney Injury defined by KDiGO criteria
次要结局
- 30 day Mortality(30 days)
研究者
Max Bell
Associate Professor
Karolinska Institutet