New Methods for Early Detection of Acute Kidney Injury After Heart Surgery
Trial Snapshot
- Phase
- Not Applicable
- Status
- Withdrawn
- Sponsor
- Karolinska Institutet
- Enrollment
- 200
- Primary Endpoint
- Acute Kidney Injury
Study Overview
Brief Summary
The investigators intend to study 2 new methods for the early detection of Acute Kidney Injury (AKI) after cardiac surgery and compare and combine the predictive abilities of these methods with established renal injury markers and epidemiological models to detect (AKI).
Detailed Description
Acute Kidney Injury is common after Cardiac surgery and occurs in up to 20% of patients (Ref Rydén).
This study will evaluate two new methods for the early detection of acute kidney injury in 200 patients undergoing elective cardiac surgery at the Karolinska Hospital.
These methods are:
- Ultrasound based measurement of the kidneys blood flow profile measured using renal resistive index (RRI). This will be measured prior and within 4 hours post surgery. Ref Herzberg, Le Dorze.
- Urine creatinine clearance will be measured in the first four hours after cardiac surgery.
The investigators will also measure known renal injury markers in blood and urine samples post operatively. These include Neutrophil gelatinise-associated lipocalin (NGAL), tissue inhibitor of metalloproteinases (TIMP-2), Insulin-like growth factor-binding protein 7 (IGFBP7), Kidney Injury Molecule 1 (KIM-1), Nephroclear, Interleukin 18 (IL-18), Fatty acid-binding protein (L-FABP), Fibulin-1, cystatin C och albumin.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •18 years and older
- •Undergoing elective cardiac surgery (Coronary artery bypass grafting, valve surgery, aortic surgery or a combination).
- •Able to understand and give written consent to partake in the study
Exclusion Criteria
- •Unable to give consent
- •Previously received a renal transplant
- •Renal failure requiring dialysis prior to surgery
- •Persistent atrial fibrillation
Outcomes
Primary Outcomes
Acute Kidney Injury
Time Frame: 48 hours
Acute Kidney Injury defined by KDiGO criteria
Secondary Outcomes
- 30 day Mortality(30 days)
Investigators
Max Bell
Associate Professor
Karolinska Institutet