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临床试验/NCT03974347
NCT03974347撤回不适用

New Methods for Early Detection of Acute Kidney Injury After Heart Surgery

Karolinska Institutet0 个研究点目标入组 200 人开始时间: 2025年1月1日最近更新:
适应症

试验速览

阶段
不适用
状态
撤回
入组人数
200
主要终点
Acute Kidney Injury

研究概览

简要总结

The investigators intend to study 2 new methods for the early detection of Acute Kidney Injury (AKI) after cardiac surgery and compare and combine the predictive abilities of these methods with established renal injury markers and epidemiological models to detect (AKI).

详细描述

Acute Kidney Injury is common after Cardiac surgery and occurs in up to 20% of patients (Ref Rydén).

This study will evaluate two new methods for the early detection of acute kidney injury in 200 patients undergoing elective cardiac surgery at the Karolinska Hospital.

These methods are:

  1. Ultrasound based measurement of the kidneys blood flow profile measured using renal resistive index (RRI). This will be measured prior and within 4 hours post surgery. Ref Herzberg, Le Dorze.
  2. Urine creatinine clearance will be measured in the first four hours after cardiac surgery.

The investigators will also measure known renal injury markers in blood and urine samples post operatively. These include Neutrophil gelatinise-associated lipocalin (NGAL), tissue inhibitor of metalloproteinases (TIMP-2), Insulin-like growth factor-binding protein 7 (IGFBP7), Kidney Injury Molecule 1 (KIM-1), Nephroclear, Interleukin 18 (IL-18), Fatty acid-binding protein (L-FABP), Fibulin-1, cystatin C och albumin.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • 18 years and older
  • Undergoing elective cardiac surgery (Coronary artery bypass grafting, valve surgery, aortic surgery or a combination).
  • Able to understand and give written consent to partake in the study

排除标准

  • Unable to give consent
  • Previously received a renal transplant
  • Renal failure requiring dialysis prior to surgery
  • Persistent atrial fibrillation

结局指标

主要结局

Acute Kidney Injury

时间窗: 48 hours

Acute Kidney Injury defined by KDiGO criteria

次要结局

  • 30 day Mortality(30 days)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Max Bell

Associate Professor

Karolinska Institutet

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