PRevention of Acute Kidney Injury Initiated With Electronic Surveillance Enhancement

Not Applicable

Completed

Interventions: Other: Conventional management arm
Other: AKI sniffer instigated AKI management

Brief Summary: Introduction: Acute kidney injury (AKI) increases mortality, hospital cost, and rate of progression toward end stage kidney disease 1-4. Early diagnosis and management of AKI is known to improve the above mentioned outcomes.

Hypothesis: the investigators will design and validate an electronic surveillance tool to screen all the ICU admissions for the earlier, more efficient diagnosis of AKI and as a result improve the outcome of AKI in ICU patients.

Methods: the investigators plan to use the patient database, and AKIN (AKI network) definition to design an electronic alert system to allow clinicians discover patients who develop AKI. Then a randomized clinical trial will be conducted to compare earlier intervention (based on Kidney Disease: Improving Global Outcomes \[KDIGO\] guidelines) initiated by AKI sniffer alert to the conventional management provided by primary physician in ICU.

Detailed Description: A prospective controlled, unblinded clinical trial will be conducted among AKI patients who are detected by the use of AKI sniffer. The investigators will randomize consecutive patients who were detected to have AKI by AKI sniffer into two groups. In one group (control group), patients will receive standard clinical care by the primary ICU physicians. The primary physicians who take care of the control subjects will be kept blinded of the results of the AKI sniffer. All the ICU physicians will receive a copy of KDIGO (March 2012) guidelines for management of AKI prior to the initiation of the patient accrual. In the intervention group, the research team will inform the primary care team about the occurrence of the AKI and provides a copy of KDIGO guidelines for management of AKI to the clinicians. Each subject will be followed until hospital discharge or for a maximum of 3 months, for clinical and laboratory data including peak serum creatinine, creatinine at the end of follow up, peak AKIN stage, along with other secondary outcomes. The investigators will exclude the prevalent cases (AKI patients who have had AKI documented in their medical records by clinicians prior to the ICU admission).

Recruitment & Eligibility

Inclusion Criteria

Exclusion Criteria

Prisoners
Patients less than 18 years old.
Lack of research authorization (in control group)
ESRD on dialysis or s/p kidney transplantation
Known AKI before admission to ICU
Moribund patients
Prevalent AKI admission in ICU (patients who have diagnosis of AKI documented in their medical records prior to ICU admission)

Arm && Interventions

Group	Intervention	Description
Conventional management arm	Conventional management arm	Patients with AKI receive standard of care in the conventional manner by the primary clinicians
AKI sniffer instigated AKI management	AKI sniffer instigated AKI management	primary clinicians for the AKI patients in this arm receive a verbal alert and reminder of KDIGO guidelines.

Primary Outcome Measures

Name	Time	Method
Change in acute kidney injury as measured by the Acute Kidney Injury Network Staging System	baseline, 4 weeks	The Acute Kidney Injury Network staging system is based on data indicating that a small change in serum creatinine influences outcome. Increases in serum creatinine or decreased urine output indicate greater kidney injury, with the stage ranging from 1 to 3. The higher the number, the greater the kidney injury.

Secondary Outcome Measures

Name	Time	Method

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