Clinical Values of Automated Electronic Alert for Acute Kidney injury-a Prospective ,Randomly Controlled Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 2,000
- 试验地点
- 1
- 主要终点
- Adverse events during hospitalization
研究概览
简要总结
Acute kidney injury (AKI) is common, serious and expensive.It is associated with significant mortality, morbidity and increased length of hospital stay.To improve clinical outcomes of AKI by early detection and timely referral to the renal,the investigators developed an electronic alert system which identifies all cases of AKI occurring in patients over 18 years.The system was also designed to collect data on AKI incidence one of the biggest tertiary hospital in China.
详细描述
A prospective, randomly controlled cohort study will be conducted agmong the patients with AKI who are detected by the use of AKI sniffer. The investigators chose to assess all inpatient serum creatinine results using a combination of "KDIGO" criteria.
The investigators randomly divided the patients into two groups:
- Usual care : patients will receive standard clinical care by the primary physicians
- AKI alert : an AKI alert will be sent to the the doctor in charge. Our team of kidney experts would give a suggestion if the the doctor in charge issue consultation applications.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adult patients with an Alert for AKI(based on KDIGO guidelines)
排除标准
- •patients already on dialysis for AKI at the time of alert
- •patients with End stage renal disease
- •patients <18 years of age
- •patients dissenting from participation according to the Ethics application
结局指标
主要结局
Adverse events during hospitalization
时间窗: from start of AKI to discharge,up to 4 weeks
cardiac shock/ need for intensive care/ cardiopulmonary resuscitation/ cardiac death/ death
Incidence of cardiovascular disease and its occurrence time followed up for 1 years
时间窗: One year after discharge
heart failure/ acute coronary syndrome/ readmission/cardiac readmission/ cardiovascular intervention or surgery
AKI recovery/stop renal replacement therapy
时间窗: from start of AKI to discharge,up to 4 weeks
Glomerular filtration rate decreased/ new occurrence proteinuria/ original proteinuria aggravation
The AKI outcome and its occurrence time followed up for 1 years
时间窗: One year after discharge
AKI recovery/stop renal replacement therapy
次要结局
- Follow-up rate after discharge(One year after discharge)
- Proportion of nephrology referral(from start of AKI to discharge,up to 4 weeks)
- Diagnostic rate of AKI at discharge(from start of AKI to discharge,up to 4 weeks)
研究者
XinLing Liang
Director of Blood Purification Center of Guangdong General Hospital
Guangdong Provincial People's Hospital