Acute Kidney Injury Biomarkers: Diagnosis and Application in Pre-operative Period of Liver Transplantation
试验速览
- 阶段
- 不适用
- 入组人数
- 122
- 试验地点
- 1
- 主要终点
- Development of Acute Kidney Injury based on novel biomarkers
研究概览
简要总结
Acute kidney injury (AKI), is a common complication of patients undergoing liver transplantation. Timing and definition of AKI, usually based on serum creatinine, have been inaccurate and inconsistent.
We hypothesized that the pattern of novel biomakers elevation could be a prognostic tool to provide information on the risk of progression of AKI, the need for RRT and mortality.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Older than 18 years
- •Reception liver transplantation
排除标准
- •CKD stage 4 / 5
- •Combined organ transplants
- •Patients receiving dialysis before liver transplant operation
结局指标
主要结局
Development of Acute Kidney Injury based on novel biomarkers
时间窗: within 7 days
Compare the timing for diagnosis of AKI comparing novel biomarkers and serum creatinine defined by Kidney Disease Improving Global Outcomes. In addition, we aim to evaluate if the pattern of elevation of the novel biomarkers provide information on progression and severity of AKI.
次要结局
- Short and long term renal outcomes(1 year)
- Association of urine chemistry and microscopy to predict acute kidney injury(within 7 days of liver transplantation)
研究者
Etienne Macedo
MD, PhD
University of Sao Paulo