Acute Kidney Injury Biomarkers: Diagnosis and Application in Pre-operative Period of Liver Transplantation
- Conditions
- Acute Kidney Injury
- Registration Number
- NCT02095431
- Lead Sponsor
- University of Sao Paulo
- Brief Summary
Acute kidney injury (AKI), is a common complication of patients undergoing liver transplantation. Timing and definition of AKI, usually based on serum creatinine, have been inaccurate and inconsistent.
We hypothesized that the pattern of novel biomakers elevation could be a prognostic tool to provide information on the risk of progression of AKI, the need for RRT and mortality.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 122
- Older than 18 years
- Reception liver transplantation
- CKD stage 4 / 5
- Combined organ transplants
- Patients receiving dialysis before liver transplant operation
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Development of Acute Kidney Injury based on novel biomarkers within 7 days Compare the timing for diagnosis of AKI comparing novel biomarkers and serum creatinine defined by Kidney Disease Improving Global Outcomes. In addition, we aim to evaluate if the pattern of elevation of the novel biomarkers provide information on progression and severity of AKI.
- Secondary Outcome Measures
Name Time Method Short and long term renal outcomes 1 year renal function and need for RRT
Association of urine chemistry and microscopy to predict acute kidney injury within 7 days of liver transplantation Association of urine chemistry and microscopy with novel biomarkers to predict AKI diagnosis and progression
Trial Locations
- Locations (1)
University of Sao Paulo
🇧🇷Sao Paulo, SP, Brazil