Acute Kidney Injury and Recovery Mode in Pediatric Liver Transplantation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 700
- 试验地点
- 1
- 主要终点
- Graft survival
研究概览
简要总结
Acute kidney injury (AKI) is a common complication after pediatric liver transplantation (PLT), and renal impairment after LT has proven to be related with increased graft failure and mortality. The recovery mode of kidney injury after PLT has not been systematically studied. Therefore, in this study we aimed to systematically evaluate prognosis of AKI after PLT, combine the recovery mode of AKI with related risk factors, and establish a relationship between AKI and CKD.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- — 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who received a liver transplant for the first time and were younger than 18 years of age at the time of transplant.
排除标准
- •Patients with incomplete clinical data. Patients with less than 5 years of follow-up. Patients who have combined multiple solid organ transplants. Patients with preoperative renal impairment (eGFR < 60ml/min/1.73 m2 or prior renal replacement therapy).
结局指标
主要结局
Graft survival
时间窗: Based on the most recent follow-up before December 31, 2023. The investigators collected clinical data of patients from 2014 to 2018, and followed enrolled participants until at least 5 years after surgery
Loss of graft is defined as patient death or secondary transplantation
次要结局
未报告次要终点
研究者
Wei Gao
MD
Tianjin First Central Hospital