Biomarkers of Acute Kidney Injury in Cardiac Surgery
- Conditions
- Acute Kidney Injury (Nontraumatic)
- Registration Number
- NCT03830450
- Lead Sponsor
- Nikola Bradic, MD
- Brief Summary
Acute kidney injury (AKI) is the most common complication in patients after cardiac surgery. An usual estimation of risk for AKI is estimation of serum creatinine, which is unreliable indicator of AKI risk. Because of that, today different biomarkers are investigated to predict incidence for development AKI after cardiac surgery. This investigation will try to find potentially risk patients for developing AKI after cardiac surgery by using conventional markers (creatinine, glomerular filtration rate) in perioperative period comparing with two different biomarkers neutrophil gelatinase-associated lipocalin (NGAL) and growth differentiation factor 15 (GDF-15) which are proven markers in patients with increased risk for AKI development.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 50
- patients scheduled for cardiac surgery (CABG, valve replacement/repair, combined)
- older than 18 years
- previous known renal disease
- patients on chronic dialysis
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Consecutive values of neutrophil gelatinase-associated lipocalin (NGAL) One year By the changing of NGAL values in consecutive measuring, predict which patients are in increased risk for development of AKI
Consecutive values of growth differentiation factor 15 (GDF-15) One year By the changing of GDF-15 values in consecutive measuring, predict which patients are in increased risk for development of AKI
Consecutive values of glomerular filtration rate (GFR) One Year By the changing of GFR values in consecutive measuring, predict which patients are in increased risk for development of AKI
- Secondary Outcome Measures
Name Time Method