Biomarkers in Estimation for Risk of Acute Kidney Injury in Cardiac Surgery
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 50
- 主要终点
- Consecutive values of neutrophil gelatinase-associated lipocalin (NGAL)
研究概览
简要总结
Acute kidney injury (AKI) is the most common complication in patients after cardiac surgery. An usual estimation of risk for AKI is estimation of serum creatinine, which is unreliable indicator of AKI risk. Because of that, today different biomarkers are investigated to predict incidence for development AKI after cardiac surgery. This investigation will try to find potentially risk patients for developing AKI after cardiac surgery by using conventional markers (creatinine, glomerular filtration rate) in perioperative period comparing with two different biomarkers neutrophil gelatinase-associated lipocalin (NGAL) and growth differentiation factor 15 (GDF-15) which are proven markers in patients with increased risk for AKI development.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patients scheduled for cardiac surgery (CABG, valve replacement/repair, combined)
- •older than 18 years
排除标准
- •previous known renal disease
- •patients on chronic dialysis
结局指标
主要结局
Consecutive values of neutrophil gelatinase-associated lipocalin (NGAL)
时间窗: One year
By the changing of NGAL values in consecutive measuring, predict which patients are in increased risk for development of AKI
Consecutive values of growth differentiation factor 15 (GDF-15)
时间窗: One year
By the changing of GDF-15 values in consecutive measuring, predict which patients are in increased risk for development of AKI
Consecutive values of glomerular filtration rate (GFR)
时间窗: One Year
By the changing of GFR values in consecutive measuring, predict which patients are in increased risk for development of AKI
次要结局
未报告次要终点
研究者
Nikola Bradic, MD
MD, Senior Lecturer
University Hospital Dubrava