Incidence, Risk Factors, and Risk Model of Acute Kidney Injury in Pediatric Patients Who Undergoing Surgery for Congenital Heart Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Patients Undergoing Surgery for Congenital Heart Disease
- Sponsor
- Samsung Medical Center
- Enrollment
- 220
- Locations
- 1
- Primary Endpoint
- Acute kidney injury as defined by KDIGO (Kidney Disease: Improving Global outcome) criteria
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
Acute kidney injury (AKI) is a major complication after cardiac surgery and has been reported to be associated with adverse outcome. Previous studies have reported that the incidence of AKI in patients undergoing surgery for congenital heart disease is as high as 42% and AKI increase the patient mortality, intensive care unit stay and hospital stay. Previous studies have reported several risk factors for AKI after congenital heart surgery, however, perioperative variables including anesthesia-related factors have not been evaluated fully. Therefore, the investigators attempt to find out independent risk factors regarding perioperative variables.
Detailed Description
Acute kidney injury (AKI) is a major complication after cardiac surgery and has been reported to be associated with adverse outcome. Previous studies have reported that the incidence of AKI in patients undergoing surgery for congenital heart disease is as high as 42% and AKI increase the patient mortality, intensive care unit stay and hospital stay. Previous studies have reported several risk factors for AKI after congenital heart surgery, however, perioperative variables including anesthesia-related factors have not been evaluated fully. In addition, a neutrophil-lymphocyte ratio (NLR), which have been reported to be a marker for systemic inflammation and associated with prognosis of cardiac and cancer patients might be able to predict development of postoperative AKI. Therefore, the investigators attempt to assess independent risk factors regarding perioperative variables including transfusion-related parameters, preoperative anemia, preoperative hypoalbuminemia, pulmonary hypertension, use of nitric oxide, use of hydroxyethyl starch, perioperative medication, hemodynamic variables and perioperative NLR.
Investigators
WonHo Kim
Assistant Professor
Samsung Medical Center
Eligibility Criteria
Inclusion Criteria
- •patients who underwent surgery for congenital heart disease between January 2012 and December 2012 in Samsung Medical Center
Exclusion Criteria
- •incomplete data for creatinine, estimated glomerular filtration rate, or urine output required to diagnose acute kidney injury
- •patients who expired within 24 hours after surgery
Outcomes
Primary Outcomes
Acute kidney injury as defined by KDIGO (Kidney Disease: Improving Global outcome) criteria
Time Frame: during seven days after surgery
Acute kidney injury as defined by KDIGO criteria (Stage 1, 2, 3)
Secondary Outcomes
- Acute kidney injury as defined by AKIN (acute kidney injury network) criteria(within 48 hours after surgery)
- acute kidney injury diagnosis defined by RIFLE criteria(during seven days after surgery)