Predicting Acute Kidney Injury After Coronary Artery Bypass Graft : a Simplified Clinical Risk Scoring Model
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Coronary Artery Bypass Surgery
- Sponsor
- Samsung Medical Center
- Enrollment
- 877
- Locations
- 1
- Primary Endpoint
- Acute kidney injury diagnosis defined by KDIGO criteria
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
Acute kidney injury after cardiac surgery is a major complication after cardiac surgery and has been reported to be associated with adverse outcome. There have been many studies reporting risk factor of acute kidney injury after cardiac surgery, but the influence of perioperative variables related to anesthesia and perioperative medication has not been evaluated fully. The investigators attempt to evaluate the influence of perioperative clinical variables including preoperative medication, preoperative albumin level, uric acid concentration, anesthesia technique, use of hydroxyethyl starch, blood glucose level, intraoperative medication, perioperative cardiac function (systolic and diastolic function) and hemodynamic variables during surgery on the incidence of acute kidney injury after coronary artery bypass graft.
Detailed Description
Acute kidney injury (AKI) after cardiac surgery is a major complication after cardiac surgery and has been reported to be associated with adverse outcome. There have been many studies reporting risk factor of acute kidney injury after cardiac surgery, but the influence of perioperative variables related to anesthesia and perioperative medication has not been evaluated fully. The investigators attempt to evaluate the influence of preoperative medication, preoperative albumin level, uric acid concentration, NL ratio, anesthesia technique, use of hydroxyethyl starch, blood glucose level, intraoperative medication, perioperative cardiac function (systolic and diastolic) and hemodynamic variables during surgery on the incidence of acute kidney injury after coronary artery bypass graft. Preoperative and postoperative diastolic dysfunction may be associated with postoperative AKI. In addition, preoperative neutrophil-lymphocyte ratio (NLR) which has been reported to be a marked for systemic inflammation and was associated with prognosis in cardiac patients undergoing coronary artery bypass graft or percutaneous coronary intervention. This preoperative or immediate postoperative NLR might be able to predict AKI after coronary artery bypass surgery.
Investigators
WonHo Kim
Assistant Professor
Samsung Medical Center
Eligibility Criteria
Inclusion Criteria
- •patients who underwent coronary artery bypass surgery during between 2010 and 2012 in Samsung Medical Center
Exclusion Criteria
- •lack of postoperative creatinine or urine output data
- •patients who expired within 24hours after surgery
Outcomes
Primary Outcomes
Acute kidney injury diagnosis defined by KDIGO criteria
Time Frame: during 7 days after surgery
Acute kidney injury diagnosis defined by KDIGO criteria (Stage 1, 2, 3) during seven days after surgery
Secondary Outcomes
- Acute kidney injury as defined by AKIN (acute kidney injury network) criteria(within 48 hours after surgery)