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Clinical Trials/NCT05017896
NCT05017896
Unknown
Not Applicable

Prediction of Acute Kidney Injury After Operation of Acute Type A Aortic Dissection Based on Multimodal Model

Qilu Hospital of Shandong University0 sites242 target enrollmentSeptember 2021

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Aneurysm, Dissecting
Sponsor
Qilu Hospital of Shandong University
Enrollment
242
Primary Endpoint
Acute kidney injury after operation
Last Updated
4 years ago

Overview

Brief Summary

Acute kidney injury is one of the most common postoperative complications of acute type A aortic dissection, which is closely related to early postoperative death. Early prevention, early diagnosis and early treatment are the key to improve the prognosis of such patients. It has been a hot topic in clinical research for a long time. Previous reports revealed a series of risk factors for acute kidney injury after aortic dissection, but limited by research design and single modal data, high quality studies were rare. The purpose of this study is to further clarify the risk factors by studying the relationship between preoperative CT renal perfusion imaging indexes and postoperative acute kidney injury; establish and externally verify the multimodal radiomics prediction model for acute kidney injury after operation of aortic dissection combining with preoperative CT renal perfusion imaging and CT angiography information by analysis methods of information fusion, feature engineering and radiomics, so as to guide the follow-up clinical practice, improve the prognosis of such patients and save medical resources.

Registry
clinicaltrials.gov
Start Date
September 2021
End Date
February 2023
Last Updated
4 years ago
Study Type
Observational
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • 18-70 years old
  • Acute type A aortic dissection diagnosed by CT angiography
  • Sign informed consent

Exclusion Criteria

  • History of chronic kidney disease
  • History of cardiovascular operation
  • Acute kidney injury has occurred before operation
  • Pregnancy status

Outcomes

Primary Outcomes

Acute kidney injury after operation

Time Frame: From date of operation until the date of acute kidney injury or date of death from any cause, whichever came first, assessed up to 30 days.

Yes; No

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