Prediction of Acute Kidney Injury After Operation of Acute Type A Aortic Dissection Based on Multimodal Model

• Conditions: Acute Kidney Injury; Aneurysm, Dissecting
• Interventions: Diagnostic Test: Normal CT Renal Perfusion imaging indexes; Diagnostic Test: Low CT Renal Perfusion imaging indexes

• Registration Number: NCT05017896
• Lead Sponsor: Qilu Hospital of Shandong University

Brief Summary

Acute kidney injury is one of the most common postoperative complications of acute type A aortic dissection, which is closely related to early postoperative death. Early prevention, early diagnosis and early treatment are the key to improve the prognosis of such patients. It has been a hot topic in clinical research for a long time. Previous reports revealed a series of risk factors for acute kidney injury after aortic dissection, but limited by research design and single modal data, high quality studies were rare. The purpose of this study is to further clarify the risk factors by studying the relationship between preoperative CT renal perfusion imaging indexes and postoperative acute kidney injury; establish and externally verify the multimodal radiomics prediction model for acute kidney injury after operation of aortic dissection combining with preoperative CT renal perfusion imaging and CT angiography information by analysis methods of information fusion, feature engineering and radiomics, so as to guide the follow-up clinical practice, improve the prognosis of such patients and save medical resources.

Detailed Description

Not available

Study Timeline

• Status Verified: 2021-08
• Study First Submitted: 2021-08-17
• Study First Submitted QC: 2021-08-23
• Last Update Submitted: 2021-08-23
• Study First Posted: 2021-08-24
• Last Update Posted: 2021-08-24
• Study Start: 2021-09
• Primary Completion: 2023-01
• Study Completion: 2023-02

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 242

Inclusion Criteria

1. 18-70 years old
2. Acute type A aortic dissection diagnosed by CT angiography
3. Sign informed consent

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Exclusion Criteria

1. History of chronic kidney disease
2. History of cardiovascular operation
3. Acute kidney injury has occurred before operation
4. Pregnancy status

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Normal Perfusion	Normal CT Renal Perfusion imaging indexes	-
Low Perfusion	Low CT Renal Perfusion imaging indexes	-

Primary Outcome Measures

Name	Time	Method
Acute kidney injury after operation	From date of operation until the date of acute kidney injury or date of death from any cause, whichever came first, assessed up to 30 days.	Yes; No