Acute Kidney Injury Following Cardiac Surgery

Completed

• Conditions: Acute Kidney Injury
• Interventions: Other: No intervention

• Registration Number: NCT03102528
• Lead Sponsor: University of Giessen

Brief Summary

Acute kidney injury (AKI) occurs in approximately one-third of patients undergoing cardiac surgery (CS), and represents one of the most significant negative predictors of patient outcome in this population. The investigators sought to examine the risk factors associated with the development of AKI and renal recovery in patients undergoing cardiac surgery at San Bortolo Hospital, Italy 2014-2015.

Detailed Description

Acute kidney injury (AKI) occurs in approximately one-third of patients undergoing cardiac surgery (CS), and represents one of the most significant negative predictors of patient outcome in this population. The investigators sought to examine the risk factors associated with the development of AKI and renal recoveryin patients undergoing cardiac surgery at San Bortolo Hospital, Italy during November 2014 - October 2015.

Study Timeline

• Study Start: 2014-11-01
• Primary Completion: 2015-10-31
• Study Completion: 2016-06-20
• Study First Submitted: 2017-03-30
• Study First Submitted QC: 2017-03-30
• Study First Posted: 2017-04-05
• Status Verified: 2019-08
• Last Update Submitted: 2019-08-27
• Last Update Posted: 2019-08-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 495

Inclusion Criteria

• Adult cardiac surgery

Exclusion Criteria

1. Missing baseline serum creatinine (defined as a serum creatinine value within 90 prior to surgery) or missing serum creatinine within 3 days before hospital discharge
2. Stage 5 chronic kidney disease (estimated glomerular filtration rate <15 ml/min/1.73 m2 or receipt of chronic dialysis)
3. Solid organ transplant recipients

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Cardiac Surgery Patients	No intervention	All adult patients undergoing cardiac surgery (elective/emergent) at San Bortolo Hospital, Vicenza, Italy during November 2014 - October 2015

Primary Outcome Measures

Name	Time	Method
Prevalence of acute kidney injury using full Kidney Disease Improving Global Outcomes criteria	within 7 days	Development of AKI within 7 days.

Secondary Outcome Measures

Name	Time	Method
Renal recovery	Within 1 month	Defined as the absence of any stage of AKI by either serum creatinine or urine output criteria at hospital discharge.