Effects of Cognitive-motor Training on Cognition, Depression and Daily Functioning in Patients With Mild Cognitive Impairment (MCI): A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 2
- 主要终点
- Short Geriatric Depression Scale (SGDS-S)
研究概览
简要总结
This randomized controlled trial evaluated the effectiveness of an immersive virtual reality (IVR) application (focused on a daily activity) to train cognitive functions and its impact on depression and the ability to perform activities of daily living (ADL) in patients with mild cognitive impairment (MCI). With a dose of two sessions per week during six weeks, the study showed significant improvements in cognitive functions and reduction in depression, with notable effects in the experimental group. This underscores the potential of IVR as a valuable tool in the management of MCI.
详细描述
Background:
The increase in cases of MCI underlines the urgency of finding effective methods to slow its progression. Given the limited effectiveness of current pharmacological options to prevent or treat the early stages of this deterioration, non-pharmacological alternatives are especially relevant.
Aim: The study aimed to evaluate the effectiveness of an immersive virtual reality (IVR) application, focused on an activity of daily living (ADL), to train cognitive functions and its impact on depression and the ability to perform ADL in patients with MCI. IVR is presented as an innovative tool with the potential to offer a promising non-pharmacological approach.
Methods:The researchers implemented a 40-minute-long intervention, twice a week for six weeks (totaling 12 sessions), using the cupboard task (based on IVR). The study included the participation of individuals with MCI, randomly distributed into control (n=12) and experimental (n=14) groups. The majority in the control group were women (75%), with a mean age of 77.67 years, and in the experimental group, women represented 57.14%, with a mean age of 74.86 years. Cognitive functions, depression, and the ability to perform ADLs were assessed. The scales used were: the Spanish version of the Montreal Cognitive Assessment (MoCA-S), the Short Geriatric Depression Scale (SGDS-S) and the Instrumental Activities of Daily Living Scale. (IADL-S), respectively.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 65 or older
- •Community-dwelling, not in nursing homes
- •Physically functional
- •Understanding and voluntary consent
- •Mild Cognitive Impairment (MCI)
- •MoCA score of 19-25
排除标准
- •Clinical dementia diagnosis
- •MoCA ≤ 18 indicating probable dementia
- •Neurological disorders including stroke or TBI in the last year
- •History of mental/psychiatric disorders
- •Substance abuse
- •Difficulty using VR headset and controllers
- •Medical conditions affecting trial participation
- •Visual/hearing impairments
- •Communication difficulties
结局指标
主要结局
Short Geriatric Depression Scale (SGDS-S)
时间窗: 6 weeks
Scores in the SGDS scale. Higher scores mean a worse outcome.
Instrumental Activities of Daily Living Scale (IADL-S)
时间窗: 6 weeks
Scores in the IADL scale. Higher scores mean a better outcome.
Spanish version of the Montreal Cognitive Assessment (MoCA-S)
时间窗: 6 weeks
Scores in the MoCA-S scale. Higher scores mean a better outcome.
次要结局
未报告次要终点
研究者
Guillermo Palacios
Principal Investigator
Universidad de Zaragoza