The Effects of Watermelon Juice Supplementation on Postprandial Vascular Endothelial Function and Blood Flow During Hyperglycemia: A Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 2
- 主要终点
- Endothelial Function
研究概览
简要总结
The purpose of this study is to test if watermelon juice supplementation improves vascular dysfunction experience during hyperglycemia.
详细描述
The objective of this pilot study is to determine the potential for watermelon juice to attenuate the reduction postprandial endothelial function and skeletal muscle microvascular blood flow (MVBF) experienced during hyperglycemia.
The investigators will attempt to answer the following hypotheses:
Hypothesis 1: Watermelon juice supplementation will attenuate the reduction in endothelial dysfunction and microvascular blood flow during an oral glucose challenge.
Hypothesis 2: Watermelon juice will increase L-arginine bioavailability during hyperglycemia and correlate with improved vascular response.
Exploratory Aim: The postprandial period is defined by increased sympathetic nervous system activity (vasoconstriction) and NO• mediated vasodilation. Heart rate variability (HRV) is a measurement of the balance of parasympathetic to sympathetic activity. The investigators will measure HRV during the oral glucose challenge to interrogate the possibility that watermelon juice can modulate the balance of blood vessel constriction and relaxation during an oral glucose
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Capable and willing to give written informed consent and understand inclusion and
排除标准
- •18-40 years of age
- •BMI between 18-29.9 kg/m2
- •Willing to allow researchers to draw blood and conduct imaging (DXA) for research purposes.
- •Exclusion Criteria:
- •Evidence or self-reported history of type 1 or 2 diabetes mellitus
- •Self-reported family history of type 2 diabetes (first degree relative with type 2 diabetes)
- •Evidence or self-report history of deep vein thrombosis, pulmonary embolism, cardiovascular, peripheral vascular, cerebral vascular, pulmonary, or renal disease
- •Allergy to watermelon
- •Use of medication known to influence study outcomes, such as:
- •Anti-diabetics (metformin)
- •Corticosteroids
- •Beta-blockers
- •Anti-coagulates
- •Use of supplements known to influence study outcomes, such as;
- •Beta-alanine
- •L-citrulline
- •Active smoking
结局指标
主要结局
Endothelial Function
时间窗: Two weeks
Flow mediated dilation
次要结局
- Postprandial Blood Flow(Two weeks)
研究者
Timothy Allerton, PhD
Postdoctoral Fellow
Pennington Biomedical Research Center