NCT06547931招募中不适用
Retrospective Analysis of a Cohort of Duffy-null Associated Neutrophil Count (DANC) Pediatric Patients
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico1 个研究点 分布在 1 个国家目标入组 150 人开始时间: 2024年6月30日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Immune neutropenia and DANC
研究概览
简要总结
There are currently no clinical and laboratory data that well characterize this neutropenia associated with the Duffy-null phenotype, particularly for pediatric subjects. In particular there are no data on the frequency of immune neutropenia in DANC neutropenic pediatric subjects.
The goal of this study is to :
- define the frequency of immune neutropenia within the cohort of DANC subjects under study
- evaluate the frequency of different degrees of neutropenia (mild-moderate-severe);
- evaluate the possible association between different degrees of neutropenia and the presence of infections.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- — 至 16 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •presence of Duffy-null phenotype
排除标准
- •absence of Duffy-null phenotype
结局指标
主要结局
Immune neutropenia and DANC
时间窗: Through study completion, an average of 1 year
Frequency of immune neutropenia, expressed as the percentage of DANC subjects testing positive for anti-neutrophil antibodies out of the total DANC subjects included in the study.
次要结局
- Distribution of mild, moderate and severe neutropenia in DANC children(Through study completion, an average of 1 year)
研究者
Alessandra Cattaneo
Biologist
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
研究点 (1)
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