Ozone and Rhinovirus-Induced Disease in Asthmatics

Completed

• Conditions: Asthma

• Registration Number: NCT00013715
• Lead Sponsor: National Institute of Environmental Health Sciences (NIEHS)

Brief Summary

In the U.S., morbidity associated with human rhinovirus (RV) infection represents a major health problem. In asthmatics, up to 80% of asthma exacerbations are associated with upper respiratory infections. Despite evidence that environmental oxidant pollutants, such as ozone, may increase the severity of viral disease, the mechanisms underlying such an effect have not been identified. This study will test the hypothesis that exposure of allergic asthmatic subjects to ambient levels of ozone directly enhances viral disease by increasing infectivity and intensifying virus-induced inflammation.

Detailed Description

In mild asthmatics, the study will investigate: (1) if exposure to ozone will enhance the viral infective process in the nasal epithelium, (2) the effect of ozone exposure on RV-induced inflammatory gene expression, mediator release and inflammatory cell influx into the upper and lower airways, and (3) the interactive effects of ozone and RV on airway reactivity. This information will improve our understanding of the risk associated with oxidant pollutant exposure in this population of individuals in whom RV infection may represent a significant health concern.

Study Timeline

• Study Start: 1999-09
• Study First Submitted: 2001-03-28
• Study First Submitted QC: 2001-03-29
• Study First Posted: 2001-03-30
• Study Completion: 2003-08
• Status Verified: 2008-08
• Last Update Submitted: 2008-08-08
• Last Update Posted: 2008-08-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

The Johns Hopkins School of Hygiene and Public Health; 🇺🇸 Baltimore, Maryland, United States