Effects of Iranian propolis supplementation on chronic kidney disease

Phase 3

Recruiting

Conditions: chronic kidney disease (CKD).

Registration Number: IRCT20191218045798N1

Lead Sponsor: Tabriz University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 44

Inclusion Criteria

The tendency to participate in the study
Having stage 2 or 3 CKD according to eGFR of 30-89 ml/min per 1.73 m2
Aged 20-80 years old

Exclusion Criteria

BMI less than 18.5 or more than 35 kg/ m2
Kidney transplant recipients
Pregnancy or breastfeeding
Having any kind of allergy or asthma
Receiving steroids or other immune system suppressors
Taking herbals in the last 3 months
Smoking, Being addicted, consuming alcohol or opioids
Professional athletes
Having chronic inflammatory disease (rheumatoid arthritis, IBD), severe depression, schizophrenia, severe liver failure, liver cirrhosis, cancers, severe infection

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Improvement in kidney function ( proteinuria, 24 hour urine, serum creatinine ). Timepoint: at the beginning and end of the study. Method of measurement: 24-hour urine collection to measure 24-hour urine volume and proteinuria, Jaffe's method for measuring serum creatinine.

Secondary Outcome Measures

Name	Time	Method
Prooxidant-antioxidant Balance. Timepoint: at the beginning and end of the study. Method of measurement: prooxidant-antioxidant Balance method.;Glycemic indices ( FBS, HbA1c, insulin ) and HOMA-IR index. Timepoint: at the beginning and end of the study. Method of measurement: biochemical assessment.;Quality of life. Timepoint: at the beginning and end of the study. Method of measurement: questionnaire.;Blood pressure. Timepoint: at the beginning and end of the study. Method of measurement: Mercury sphygmomanometer.