Predictors of Outcomes in Pulmonary Hypertension of the Newborn
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 60
- 主要终点
- In-hospital mortality
研究概览
简要总结
This prospective cohort study aims to identify the clinical, laboratory, and echocardiographic predictors of outcomes among neonates diagnosed with persistent pulmonary hypertension of the newborn at Assiut University Children Hospital.
详细描述
Persistent pulmonary hypertension of the newborn (PPHN) is a serious condition characterized by failure of the normal postnatal decline in pulmonary vascular resistance, leading to severe hypoxemia. Outcomes vary widely, ranging from complete recovery to death.
This observational study will include term and preterm neonates admitted to the NICU with clinical and echocardiographic evidence of pulmonary hypertension. Clinical, laboratory, and echocardiographic parameters will be recorded to identify predictors of mortality and other adverse outcomes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 28 Days（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •- Neonates (term and preterm) admitted to the NICU
- •Clinical and echocardiographic evidence of pulmonary hypertension
- •Written informed consent from parents or legal guardians
排除标准
- •- Major structural cyanotic congenital heart disease
- •Lethal congenital anomalies or chromosomal abnormalities incompatible with survival
研究组 & 干预措施
Single cohort: Neonates with PPHN
Term and preterm neonates with clinical and echocardiographic evidence of persistent pulmonary hypertension who will be followed for clinical, laboratory, and echocardiographic predictors of outcome.
结局指标
主要结局
In-hospital mortality
时间窗: Up to 30 days
Proportion of neonates with persistent pulmonary hypertension who die before hospital discharge.
次要结局
- Duration of mechanical ventilation(Up to 30 days)
- Duration of oxygen therapy(Up to 30 days)
- Use of sildenafil(Up to 30 days)
- Use of inotropes(Up to 30 days)
- Duration of NICU stay(Up to 30 days)
- Time to echocardiographic resolution(Up to 30 days)
研究者
Aya Saleh Mohammed
Resident Physician
Assiut University