JPRN-C000000422
Completed
Phase 4
Randomized double blind comparative study of nipradilol, an alfa-1,beta-blocker with a nitric oxide donative action, and timolol, a non-selective beta-blocker, on the visual field in Japanese patients with normal-tension glaucoma. - Japanese Normal Tension Glaucoma Treatment Study (JNTGTS)
Conditionsormal Tension Glaucoma
Overview
- Phase
- Phase 4
- Status
- Completed
- Sponsor
- KOWA company, ltd.
- Enrollment
- 150
Overview
Brief Summary
The effect of topical nipradilol and timolol on progression of visual field damage and IOP was found to be equivalent in Japanese NTG patients whose untreated IOP was 14mmHg.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 20years-old to 60years-old (—)
- Sex
- All
Inclusion Criteria
- Not provided
Exclusion Criteria
- •Patients with \-Cataract which affects the visual field or corrected vision of \<0\.8 \-Refraction of \<\-0\.8D or \>5\.0D \-A history of invasive eye surgery \-Complication with serious retinal disease that affects the visual field \-Complications which require treatment using the following prohibited drugs: i.e., drugs that influence intraocular pressure or blood flow, and drugs that have neuroprotective action \-Complication with diabetes mellitus \-Pulse rate of 50/min or less \-Routine systolic blood pressure of 110 mmHg or below \-Patients who are pregnant, nursing or are suspected of being pregnant
Investigators
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