Number of Participants Diagnosed With Sarcoidosis by Bronchoscopic Transbronchial Needle Aspiration After COVID- 2019 .

Completed

• Conditions: COVID-19; Sarcoidosis
• Interventions: Procedure: flexible bronchoscopy

• Registration Number: NCT06043882
• Lead Sponsor: Ain Shams University

Brief Summary

The goal of this observational study is to learn about sarcoidosis development after COVID-19 infection.

The main question it aims to answer is:

* prevalence of Sarcoidosis among patients previously infected with COVID-19.

Participants will:

* provide previous positive RT-PCR for COVID-19

* Have computed tomography of the Chest with suggestive findings of sarcoidosis

* Have bronchoscopic guided biopsies and pathological analysis to detect number of patients with sarcoidosis.

Detailed Description

This prospective cross sectional study was performed on a total of 55 patients with mediastinal and /or hilar lymphadenopathy with or without lung infiltrates referred to Bronchoscopy unit , Chest department, Ain-Shams University hospital for biopsy taking and diagnosis.

All patients were subjected to the following : history taking , clinical examination , radiological assessment by computed tomography (CT )chest , fiberoptic bronchoscopy where biopsies were taken either by conventional-Trans-bronchial needle aspiration (c-TBNA) , endo-bronchial ultrasound (EBUS-TBNA) or direct forceps biopsies and sent for histopathological examination and if the patient had past history of COVID-19 infection with previous positive reverse transcriptase- polymerase chain reaction assay (RT-PCR).

Study Timeline

• Study Start: 2022-11-01
• Primary Completion: 2023-04-30
• Study Completion: 2023-05-30
• Status Verified: 2023-07
• Study First Submitted: 2023-08-31
• Study First Submitted QC: 2023-09-17
• Study First Posted: 2023-09-21
• Last Update Submitted: 2023-09-21
• Last Update Posted: 2023-09-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 55

Inclusion Criteria

• All adult patients with previous positive RT-PCR for COVID -19 and CT chest findings of mediastinal and or hilar lymphadenopathy with or without lung infiltrate will be included. .

Exclusion Criteria

• Patients younger than 18 years old Patients
• Patients refuse to participate in the study
• Patients previously diagnosed as sarcoidosis

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
the relation between COVID-19 infection and the development of sarcoidosis .	flexible bronchoscopy	All patients were subjected to the following : history taking , clinical examination , radiological assessment by CT chest , fiberoptic bronchoscopy where biopsies were taken either by conventional TBNA (c-TBNA) , EBUS-TBNA or direct forceps biopsies and sent for histopathological examination and if the patient had past history of COVID-19 infection with previous positive RT-PCR.

Primary Outcome Measures

Name	Time	Method
Number and risk factors of sarcoidosis development after COVID -19 infection as diagnosed by TBNA guided tissue biopsies in bronchoscopy unit, chest department, Ain Shams university.	6 months	Number of COVID-19 patients diagnosed by TBNA guided biopsies as having granulomatous tissue suggesting sarcoidosis development, and risk factors that associate its development.

Trial Locations

Locations (1)

Hoda atiatullah; 🇪🇬 Cairo, Egypt