HPV Prevalence in the Mouth and Oropharynx of the Tonsillectomy Population
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 937
- 试验地点
- 8
- 主要终点
- Occurrence of HPV in tonsils and in oral scrape sample
研究概览
简要总结
The principal aim of this study is to provide vital current data on the prevalence, distribution and natural history of Human Papilloma Virus (HPV) infection in the mouth. This data is an essential requirement for the assessment, development and evaluation of cost effectiveness of prophylactic vaccination and screening programmes.
详细描述
Patients undergoing a tonsillectomy operation for non-cancerous reasons will be recruited for this study. They will be asked to complete two questionnaires (study and sexual practices), provide saliva, urine and a blood sample. Following anaesthesia, oropharyngeal brushings and a tonsillectomy will be performed and all the samples will be processed for evidence of HPV infection.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 65 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects undergoing tonsillectomy for non cancer reasons including operations for: recurrent tonsillitis, asymmetric tonsils, snoring surgery or obstructive sleep apnoea
- •Age - 0 to 65 years
- •Subject or legal guardian has given informed written consent
排除标准
- •Subjects undergoing adenoidectomy alone with no tonsillectomy
- •Subjects with previous oropharyngeal cancer or oral cancer, or any other head and neck cancer such as nasopharyngeal or laryngeal cancer that is currently undergoing or has previously been diagnosed or treated
- •Learning disability preventing an adult over 16 years old from giving their own consent
结局指标
主要结局
Occurrence of HPV in tonsils and in oral scrape sample
时间窗: 36 months
Presence of HPV result
次要结局
- HPV vaccination status(36 months)