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临床试验/NCT02785328
NCT02785328已完成不适用

Sleep-dependent Memory Consolidation in Children With Sleep Diseases

Hospices Civils de Lyon2 个研究点 分布在 1 个国家目标入组 71 人开始时间: 2016年2月最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
71
试验地点
2
主要终点
Memory performances

研究概览

简要总结

Sleep exerts a dual effect on learning: on the one hand, good sleep quality allows good daytime aptitudes leading to knowledge acquisition. On the other hand, sleep after learning is necessary for knowledge consolidation. A key role of sleep has clearly been demonstrated in memory consolidation in adults. Sleep leads to strengthen memory by promoting brain plasticity. Surprisingly, sleep influence on learning stabilization has scarcely been studied during childhood and in children affected by sleep disorders. Yet, sleep disorders concern almost 30% of children and are frequently related to a worsening in academic performances. Classical neuropsychological evaluations of these children, based on daytime learning, often fail to determine cognitive profiles explaining their academic difficulties. The investigators hypothesize that a lack of sleep-dependent consolidation could take an active part in these children's cognitive and academic difficulties. This proposal aims at characterizing interactions between sleep, learning and memory processes that have not been studied in children of elementary school age (6-12 years). The investigators will evaluate sleep-dependent memory consolidation processes in children with sleep disorders before and after treatment and healthy controls. Neuropsychological testing and academic performances will be also evaluated.. The comparison of performances obtained before and after medical treatment, will allow to understand whether normalisation of sleep quality permits the restoration of sleep-dependent memory consolidation.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Parallel
主要目的
Basic Science
盲法
None

入排标准

年龄范围
6 Years 至 12 Years(Child)
性别
All
接受健康志愿者

入选标准

  • aged between 6 and 12 y
  • referred to the HFME for a suspicion of sleep apnea
  • narcolepsy
  • centro-temporal epilepsy
  • high intellectual potential
  • children without sleep disorders will be included in the healthy control group.

排除标准

  • 未提供

研究组 & 干预措施

obstructive sleep apnoea

Experimental

The objective of this task is to evaluate the sleep-dependent consolidation abilities before and after treatment in children suffering from obstructive sleep apnoea syndrome.

干预措施: memory evaluation at V1 and V2 (with treatment) (Other)

narcolepsy

Experimental

The objective of this task is to evaluate the sleep-dependent consolidation abilities before and after treatment in children suffering from narcolepsy.

干预措施: memory evaluation at V1 and V2 (with treatment) (Other)

BECTS (Benign epilepsy with centro-temporal spikes)

Experimental

The objective of this task is to evaluate the sleep-dependent consolidation abilities before and after treatment in children suffering from BECTS.

干预措施: memory evaluation at V1 and V2 (with treatment) (Other)

high intellectual potential

Experimental

The objective of this task is to evaluate the sleep-dependent consolidation abilities in children with high intellectual potential.

干预措施: memory evaluation at V1 (without treatment) (Other)

healthy children

Experimental

The objective of this task is to evaluate the sleep-dependent consolidation abilities in healthy children.

干预措施: memory evaluation at V1 and V2 (without treatment) (Other)

结局指标

主要结局

Memory performances

时间窗: 6 months

memory test : Björn Rasch, et al. (2007)

次要结局

  • sleep latency (time before sleeping after closing eyes)(3 months and 6 months)
  • number of awakenings(3 months and 6 months)
  • number of Stage 2(3 months and 6 months)
  • sleep efficiency (sleep time/time on bed)(3 months and 6 months)
  • number of Stage 1(3 months and 6 months)
  • numbers of rapid eye movements(3 months and 6 months)
  • WASO (wake after sleep onset)(3 months and 6 months)
  • depression and anxiety(3 months and 6 months)
  • total sleep time (TST)(3 months and 6 months)
  • Slow-wave sleep (SWS) percentages(3 months and 6 months)
  • SWS time(3 months and 6 months)
  • PS percentages(3 months and 6 months)
  • PS latency (time between start of sleep and start of PS)(3 months and 6 months)
  • total cycle time (TCT)(3 months and 6 months)
  • TCT/TST ratio(3 months and 6 months)
  • O2 desaturation(3 months and 6 months)
  • attention assessment(3 months and 6 months)
  • Intellectual Quotient(3 months and 6 months)
  • apnoea/hypopnoea index(3 months and 6 months)
  • micro-arousal index(3 months and 6 months)
  • short and long term memory(3 months and 6 months)
  • executive functions(3 months and 6 months)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (2)

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