Glioblastoma Platelet Activation Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 21
- 试验地点
- 1
- 主要终点
- Mean P-selectine expression in all platelets
研究概览
简要总结
Glioblastoma face an increased risk of venous or arterial thromboembolism. Furthermore, the most frequent immune cells in glioblastoma are tumor associated macrophages, which find theirself in an anti-inflammatory (M2) phenotype.
Increased conjugates between circulating platelets and monocytes reflect an pro-inflammatory status.
详细描述
Glioblastoma face an increased risk of venous or arterial thromboembolism. Furthermore, the most frequent immune cells in glioblastoma are tumor associated macrophages, which find theirself in an anti-inflammatory (M2) phenotype.
Increased conjugates between circulating platelets and monocytes reflect an pro-inflammatory status.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •MR-morphological suspicion for glioblastoma
- •informed consent
排除标准
- •no informed consent
结局指标
主要结局
Mean P-selectine expression in all platelets
时间窗: 01/ 2016 - 10/ 2016
Mean CD63 expression in all platelets
时间窗: 01/ 2016 - 10/ 2016
Mean CD40 Expression in all platelets
时间窗: 01/ 2016 - 10/ 2016
Mean platelet-monocyte-conjugate formation in the monocyte population
时间窗: 01/ 2016 - 10/ 2016
次要结局
未报告次要终点
研究者
Sascha Marx
Dr. med.
University Medicine Greifswald