NCT00253669已完成不适用
Pilot Study of Thrombophilic States in Newly Diagnosed Patients With High-Grade Gliomas
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins9 个研究点 分布在 1 个国家目标入组 110 人开始时间: 2005年4月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 110
- 试验地点
- 9
- 主要终点
- Thrombosis-free survival as assessed by objectively documented deep vein thrombosis or pulmonary embolism
研究概览
简要总结
RATIONALE: Patients with gliomas may be at risk for developing blood clots. Learning about the risk factors for developing blood clots may help doctors plan better treatment for gliomas.
PURPOSE: This clinical trial is studying risk factors for developing blood clots in patients who are undergoing cancer treatment for newly diagnosed gliomas.
详细描述
OBJECTIVES:
Primary
- Determine the overall hazard rate of first venous thromboembolism per person-year of follow-up in patients undergoing antineoplastic therapy for newly diagnosed high-grade gliomas.
- Correlate ABO blood type with incidence of venous thromboembolism in these patients.
- Correlate factor VIII level with incidence of venous thromboembolism in these patients.
Secondary
- Determine the overall and individual incidence rate of thromboembolism in these patients.
- Correlate clinical variables, such as type of antineoplastic treatments, Karnofsky performance status, and type of tumor, with incidence of venous thromboembolism in these patients.
- Correlate demographic factors, such as age, with incidence of venous thromboembolism in these patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 120 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Thrombosis-free survival as assessed by objectively documented deep vein thrombosis or pulmonary embolism
时间窗: until dvt or death
次要结局
- ABO blood group association with venous thromboembolism (VTE) factor VIII activity and VTE as assessed by laboratory test result at study entry(on study)
研究者
研究点 (9)
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