NCT01784952已完成不适用
Consumption of Whole Grains and Legumes Modulates the Genetic Effect of the APOA5 -1131C Variant
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 200
- 试验地点
- 2
- 主要终点
- Triglyceride
研究概览
简要总结
We examined whether a substitution of whole grains and legumes for refined rice in a high carbohydrate diet (about 65% of energy derived from carbohydrate) may modify the effect of this variant on changes in apolipoprotein A-V (apoA-V) and triglyceride concentrations.
详细描述
We genotyped the APOA5 -1131T>C in individuals with impaired fasting glucose (IFG) or newly diagnosed type 2 diabetes, who were randomly assigned to either a group ingesting whole grain and legume meals daily or a control group for 12 weeks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 25 Years 至 72 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects who were in in impaired fasting glucose (IFG, 100≤ fasting glucose <126 mg/dL) and newly diagnosed type 2 diabetes (fasting glucose ≥126 mg/dL) were referred to the Department of Family Medicine or Internal Medicine. They were rechecked for their health and lipid profiles, and then those who satisfied the study criteria were recommended to participate in the dietary intervention program
排除标准
- •Current and/or past history of cardiovascular disease including angina
- •Liver or kidney dysfunction
- •Thyroid or pituitary disease
- •Unstable weight loss/gain (≥2 kg) over the previous 6months
- •Pregnancy or lactation. Subjects who were taking medication were also excluded
研究组 & 干预措施
Whole grains and lequmes
Experimental
干预措施: Dietary intervention (Dietary Supplement)
refined rice
Placebo Comparator
干预措施: Dietary intervention (Dietary Supplement)
结局指标
主要结局
Triglyceride
时间窗: change from baseline in TG at 12 weeks
次要结局
- Apolipoprotein A5(Change from baseline in ApoA5 at 12 weeks)
研究者
研究点 (2)
Loading locations...
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