NCT01895387已完成不适用
Replacing With Whole Grains and Legumes Reduces Lipoprotein-associated Phospholipase A2 (Lp-PLA2) Activities in Plasma and Peripheral Blood Mononuclear Cells in Patients With Prediabetes or Newly Diagnosed Type 2 Diabetes
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Plasma Lp-PLA2 activity
研究概览
简要总结
We determined the effects of dietary intervention (replacement of refined rice with whole grains and legumes and a high intake of vegetables) on circulating Lp-PLA2 activity and enzyme activity in peripheral blood mononuclear cells (PBMCs) in patients with impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or newly-diagnosed type 2 diabetes.
详细描述
Ninety-nine patients with impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or newly-diagnosed type 2 diabetes were randomly assigned to either a control group (usual diet with refined rice) or the whole grain group.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 39 Years 至 74 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects who were in in impaired fasting glucose (IFG, 100≤ fasting glucose <126 mg/dL)
- •or newly diagnosed type 2 diabetes (fasting glucose ≥126 mg/dL)
排除标准
- •current and/or past history of cardiovascular disease including angina
- •liver or kidney dysfunction
- •thyroid or pituitary disease
- •unstable weight loss/gain (≥2 kg) over the previous 12 months
- •pregnancy or lactation
- •taking medications or supplements
结局指标
主要结局
Plasma Lp-PLA2 activity
时间窗: Change from baseline in Lp-PLA2 at 12 weeks
次要结局
- PBMC Lp-PLA2 activity(Change from baseline in PBMC Lp-PLA2 at 12 weeks)
研究者
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Consumption of Whole Grains and Legumes Modulates the Genetic Effect of the APOA5 -1131C VariantSubjects With Mild Hypertriglyceridemia in Type 2 DMNCT01784952Yonsei University200
已完成
不适用
Effects of Replacing Starchy Vegetables and Refined Grains With Beef on Cardio-metabolic Disease Risk Factors (S53)Diet ModificationNCT03925142Purdue University43
已完成
不适用
The Effects of Lentil-containing Food Products on Satiety and Food IntakeAppetiteSatietyFood IntakeNCT03128684University of Guelph24
尚未招募
不适用
Effects of a Legume-rich Diet in the Context of the Planetary Health Diet Compared to a Western-oriented Dietary Pattern in Participants with Increased Cardiometabolic RiskCardiovascular DiseasesNCT06700954University of Bonn100
已完成
不适用
Promoting Gastrointestinal Health and Reducing Subclinical Inflammation in Obese IndividualsOverweightObesityNCT02602496University of Nebraska Lincoln52