Optimisation of perioperative cardiovascular management to improve surgical outcome II
- Conditions
- Major elective gastrointestinal surgerySurgery
- Registration Number
- ISRCTN39653756
- Lead Sponsor
- Queen Mary University of London
- Brief Summary
2019 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/30647034 protocol (added 12/02/2020)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 2502
1. Age 65 years and over
2. Patients undergoing major elective surgery involving the gastrointestinal tract that is expected to take longer than 90 minutes
1. Inability or refusal to provide patient consent
2. Clinician refusal (including intention to monitor cardiac output from the start of surgery regardless of study group allocation)
3. American Society of Anesthesiologists (ASA) score of I
4. Patients expected to die within 30 days
5. Acute myocardial ischaemia within 30 days prior to randomisation
6. Acute pulmonary oedema within 30 days prior to randomisation
7. Contra-indication to low-dose inotropic medication
8. Pregnancy at time of enrolment
9. Previous enrolment in the OPTIMISE II trial
10. Current participation in another clinical trial of a treatment with a similar biological mechanism or primary outcome measure
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method