Training to improve dyspnoea

Not Applicable

Completed

• Conditions: Chronic obstructive pulmonary disease, unspecified; Chronic obstructive pulmonary disease (COPD); Respiratory

• Registration Number: ISRCTN45695543
• Lead Sponsor: niversity Hospitals of Leicester

Brief Summary

2019 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/31367635 protocol (added 02/08/2019) 2021 Results article in http://dx.doi.org/10.1136/thoraxjnl-2021-217072 (added 13/12/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-10-19
• Study Completion: 2021-09-30
• Last Update Posted: 27 December 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 104

Inclusion Criteria

1. Participant is willing and able to give informed consent for participation in the study
2. Male or female, aged 40 years or above
3. Confirmed diagnosed of COPD
4. MRC Score of 2 or more on the conventional 1-5 scale. (walk slower than people of the same age on the level or stops for breath when walking at own pace on the level)
5. Able to read and write in English
For the sub studies ExPORt and CORe (added 23/05/2020):
1. Participant is willing and able to give informed consent for participation in the study
2. Referred to the study through a clinical service (pulmonary rehabilitation or admission with COVID-19)

Exclusion Criteria

1. Significant disease (other than COPD) that could cause dyspnoea or exercise limitation
2. Contraindications for exercise (unstable cardiovascular disease; hypertension etc, a full list is described by the American College of Sports Medicine and is routine deployed)
3. Inability/unwillingness to use the device
4. Contraindications to using HFAO device (including severe right heart failure with hypotension), current severe haemoptysis, ineffective cough, rib fractures, pregnancy, current or recent pneumothorax, epilepsy, current pulmonary embolism, oesophageal varices, recent thoracic, upper gastro-intestinal tract or facial surgery).
5. Previously engaged in exercised based research or pulmonary rehab in the last 6 months
6. Inability to secure informed consent
7. Those unable to communicate in full English will be excluded as the user manual is only available in English
8. Currently involved in exercise based research

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Dyspnoea is measured using the Dyspnoea domain of the Chronic Respiratory Questionnaire and the COPD assessment test at baseline and after 8 weeks of the intervention (typically 9 weeks later)