Interferential Electrical Stimulation and Vasodilatation in Healthy Individuals

Completed

• Conditions: Decreased Vascular Flow
• Interventions: Device: Interferential; Device: Interferential Placebo

• Registration Number: NCT01450371
• Lead Sponsor: Hospital de Clinicas de Porto Alegre

Brief Summary

Interferential electrical stimulation (IES) increases local blood flow. It is not known whether increases in blood flow may be caused by inhibition of sympathetic activity, mediated by muscle metaboreflex activity. The purpose of this study was to evaluate the effect of IES on metaboreflex activation in healthy subjects.

Detailed Description

The study sample consisted of 11 healthy young individuals. All subjects were non-smokers, non-obese and free of any signs or symptoms of disease, as revealed by medical history, physical examination and electrocardiogram at rest and during cardiopulmonary exercise testing. Exclusion criteria were pregnancy, breast-feeding, alcohol or drug abuse, and any medication with potential effects on cardiovascular variables. Subjects were asked not to drink caffeine-containing drinks or exercise for at least 12 and 48 hours, respectively, before the experimental protocols.

Study Timeline

• Study Start: 2011-07
• Study First Submitted: 2011-08-26
• Study First Submitted QC: 2011-10-10
• Study First Posted: 2011-10-12
• Primary Completion: 2012-09
• Study Completion: 2012-10
• Status Verified: 2013-01
• Last Update Submitted: 2013-01-23
• Last Update Posted: 2013-01-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 11

Inclusion Criteria

• Subjects are non-smokers
• non-obese
• and free of any signs or symptoms of disease

Exclusion Criteria

• Pregnancy
• breast-feeding
• alcohol or drug abuse
• medication with potential effects on cardiovascular variables

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Interferential	Interferential	The individuals are treated acutely with interferential electrical stimulation (IES) during 30 min, providing a continuous flow of symmetrical rectangular interferential current biphasic pulses using bipolar electrodes with two channels and a slope of 1/5/1. The fixed current is adjusted to 4000 Hz, with the current AMF at 100 Hz and an AMF variation of 25 Hz (25% of AMF).
Placebo	Interferential Placebo	The same instructions and electrode positions were provided to the placebo, although the equipment did not provide any stimulation current

Primary Outcome Measures

Name	Time	Method
Muscle Metaboreflex Reflex	Participants will be followed for the duration of metaboreflex activity (up to 30 minutes)	Calf blood flow

Trial Locations

Locations (3)

University of Brasilia; 🇧🇷 Brasilia, DF, Brazil

Hospital de Clinicas de Porto Alegre; 🇧🇷 Porto Alegre, RS, Brazil

Gaspar Rogério da Silva Chiappa; 🇧🇷 Porto Alegre, RS, Brazil