NCT00447044已完成不适用
Combined Effects of Nutritional and Exercise Countermeasures
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 31
- 试验地点
- 2
- 主要终点
- Fractional synthetic rate of muscle growth.
研究概览
简要总结
The purpose of this study is to see if a combination of resistance exercises and amino acid capsules can reduce muscle loss and maintain muscle function during bedrest. This experiment will imitate many of the physical conditions experienced by astronauts during space flight by examining the effects of resistance exercise or nutrition on muscle during 2 days of bedrest. The diet of astronauts will also be imitated by providing diets in the General Clinic Research Center.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-50 years of age
- •Availability of transport and ability to report to Research Center at appointed times
排除标准
- •Subjects with limiting or unstable angina or a cardiology confirmed ECG which demonstrates cardiac abnormalities such as > 0.2 mV horizontal or downsloping ST segment depression, frequent arrhythmia's (>10 PVC/min), or valvular disease.
- •Subjects with vascular disease as determined by a combination of risk factors of peripheral atherosclerosis, namely hypertension, obesity, diabetes, hypercholesterolemia and/or evidence of venous or arterial insufficiency upon palpitation of femoral, popliteal, and pedal arteries.
- •Any history of hypo- or hyper-coagulation disorders including subjects taking Coumadin or with a history of DVT or PE at any point in their lifetime.
- •Any subject that has a chronically elevated systolic pressure >170 or a diastolic blood pressure > 100 will be excluded. Subjects may be included if they are taking blood pressure medication and have a blood pressure below these criteria.
- •Any subject with an uncontrolled metabolic disease including liver or renal disease.
- •Fasting blood glucose of >126 mg/dl on two separate occasions
- •Presence of acute illness or metabolically unstable chronic illness.
- •Any subject currently on weight-loss diet.
- •Inability to abstain from smoking for duration of study.
- •Recent ingestion of anabolic steroids (within 6 months).
- •Subjects with atrial fibrillation, history of syncope, angina or congestive heart failure.
- •Subjects with a recently (6 months) treated cancer other than Basal Cell Carcinoma.
- •Pregnancy/lactation.
- •Any other condition or event considered exclusionary by the PI and covering faculty
结局指标
主要结局
Fractional synthetic rate of muscle growth.
时间窗: two days.
次要结局
未报告次要终点
研究者
研究点 (2)
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