Malnutrition in Older Cancer Patients
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Hematopoietic and Lymphoid Cell Neoplasm
- Sponsor
- M.D. Anderson Cancer Center
- Enrollment
- 180
- Locations
- 1
- Primary Endpoint
- Mortality
- Status
- Active, Not Recruiting
- Last Updated
- 5 months ago
Overview
Brief Summary
This trial studies how well comprehensive nutritional geriatric assessments work in identifying malnutrition in older cancer participants. Comprehensive nutritional geriatric assessments may help doctors learn about ways to check for malnutrition (loss of weight/appetite that may result in health problems) that is due to cancer or cancer treatment.
Detailed Description
PRIMARY OBJECTIVES: I. To evaluate whether nutritional status, as determined by each of 4 screening tools (Mini Nutritional Assessment \[MNA\], weight loss, body mass index \[BMI\], and lean muscle mass), correlates with 6-month and 12-month mortality in older cancer patients after geriatric assessment, after adjusting for covariates. II. To evaluate whether nutritional status, as determined by each of by 4 screening tools (MNA, weight loss, BMI, and lean muscle mass) correlates with 6-month and 12-month unplanned hospitalization in older cancer patients who undergo geriatric assessment, after adjusting for covariates. III. To evaluate whether nutritional status, as determined by each of 4 screening tools (MNA, weight loss, BMI, and lean muscle mass) correlates with 6-month and 12-month hospital readmissions in older cancer patients who undergo geriatric assessment, after adjusting for covariates. OUTLINE: Participants undergo nutritional geriatric assessment over 15 minutes in person or on the phone every 3 months for 12 months.
Investigators
Eligibility Criteria
Inclusion Criteria
- •With hematologic and solid tumor cancers.
- •Undergo a comprehensive geriatric assessment by a geriatrician.
Exclusion Criteria
- •Unable or unwilling to sign consent form.
- •Life expectancy under 6 months.
Outcomes
Primary Outcomes
Mortality
Time Frame: At 6 months
The association between nutrition status and mortality (6-month and 1-year mortality since geriatric assessment) will be assessed by logistic regression analysis, considering mortality as a response variable. Univariate logistic regression analysis will be used to estimate the crude odds ratio, and multivariable logistic regression will be used to estimate the adjusted odds ratio, after controlling for potential confounder variables, such as age, race, cancer type, cancer stage, co-morbidity, cognitive status), and frailty. ROC curve to predict 6-month and 1-year mortality will be constructed for nutritional status, as determined by each screening tool. The area under the ROC curve, sensitivity, and specificity and 95% confidence intervals will be obtained for each screening tool.
Secondary Outcomes
- Mortality(At 1 year)
- Unplanned hospitalization rate(At 6 months and 1 year)
- Hospital readmission rate(At 6 months)
- Re-hospitalization rate(At 1 year)