Role of Lung and Diaphragm Ultrasound in Predicting Extubation and Weaning of Mechanically Ventilated Patients in Intensive Care Unit
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Success rate of extubation
研究概览
简要总结
This study aims to evaluate the role of lung ultrasound score (LUS), diaphragmatic excursion (DE), and diaphragmatic thickening fraction (DTF) as predictors of successful extubation in mechanically ventilated patients in the intensive care unit (ICU). It also compares these ultrasound-based parameters to traditional weaning criteria.
详细描述
Mechanical ventilation is a necessary life support technology for critically ill patients. The weaning outcome affects the morbidity and mortality of patients when their primary disease improves.
Moreover, lung ultrasonography can be used as an effective measure in the evaluation of lung aeration which is useful during the weaning procedure as it reflect the aeration loss and consequently predict the respiratory distress in the postintubation period, a validated score termed the lung ultrasound score(LUS) can be used to evaluate the loss of lung aeration.
Numerous data measured through diaphragmatic ultrasonography have been recommended for the same purpose, which involve measurement of diaphragmatic muscle movement during inspiration or excursion during the respiratory cycle (DE), and diaphragmatic muscle thickening or diaphragmatic thickening fraction (DTF).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients who will meet the following weaning criteria undergo Spontaneous Breathing Trial, which include,
- •Improvement of disease acute phase which necessitated mechanical ventilation.
- •Stable neurological status.
- •No hemodynamic instability (heart rate ≤ 120/min, systolic blood pressure higher than 90 mmHg and lower than 160 mmHg) in the absence of any vasoactive support therapy.
- •PaO2>60 mm Hg or SaO2 ≥ 90% or more with FiO2 ≤ 0.
- •Afebrile and there were no significant abnormalities in the electrolyte levels.
排除标准
- •Hemodynamic unstable patients
- •Patients with severe intracranial disease,
- •Tracheostomy.
- •Severe intensive care unit (ICU) acquired neuromyopathy, with primary unilateral/bilateral absence of diaphragmatic mobility,
- •Patients who had previously failed spontaneous breathing trial (SBT).
结局指标
主要结局
Success rate of extubation
时间窗: 48 hours post-extubation
Success rate of extubation was recorded
次要结局
- Diaphragmatic Thickening Fraction (DTF)(Within 1 hour prior to extubation)
- Diaphragmatic Excursion (DE)(Within 1 hour prior to extubation)
- Lung Ultrasound Score (LUS)(Within 1 hour prior to extubation)
研究者
Ahmed Mabrouk Elsayed Ibrahim
Resident at Anesthesia, Surgical Intensive Care and Pain Management, Faculty of Medicine, Kafr Elsheikh University, Kafr Elsheikh, Egypt.
Kafrelsheikh University