The Role of Lung and Diaphragm Ultrasonography in Predicting Clinical Progression in Hypoxemic Respiratory Failure

Completed

• Conditions: Diaphragm Ultrasonography; Lung Ultrasound; Hypoxemic Respiratory Failure

• Registration Number: NCT06706830
• Lead Sponsor: Simge Evren

Brief Summary

The goal of this observational study is to evaluate whether the risk of intubation in patients with hypoxemic respiratory failure who were monitored in the intensive care unit and received non-invasive mechanical ventilation and high-flow nasal oxygen treatment could be predicted using lung and diaphragm ultrasound.

The main question it aims to answer is:

Can lung and diaphragm ultrasound predict the risk of intubation in patients with hypoxemic respiratory failure?

Detailed Description

Between January 1, 2024, and May 1, 2024, the diaphragm thickness fraction, excursion, LUS score, ROX index, and the LUSS/ROX index ratio were evaluated using lung and diaphragm ultrasound in 91 patients admitted to the intensive care unit with a diagnosis of hypoxemic respiratory failure. These evaluations were performed at the 6th, 12th, 24th, and 48th hours of their ICU stay, and during intubation if the decision for intubation was made

Study Timeline

• Study Start: 2024-01-01
• Primary Completion: 2024-05-01
• Study Completion: 2024-08-23
• Status Verified: 2024-11
• Study First Submitted: 2024-11-11
• Study First Submitted QC: 2024-11-22
• Last Update Submitted: 2024-11-22
• Study First Posted: 2024-11-27
• Last Update Posted: 2024-11-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 91

Inclusion Criteria

-PaO2 <60 mmHg detected in arterial blood gas samples at the time of admission to the intensive care unit

Exclusion Criteria

• Under the age of 18
• History of lung and diaphragm surgery
• Congenital, acquired or traumatic diaphragmatic hernia
• Diaphragm paralysis
• Hemodynamic instability requiring vasoactive drug support
• Do not agree to participate in the study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Lung and diaphragm ultrasound evaluation for risk of intubation	48 hours	Lung and diaphragm ultrasound can predict risk of intubation

Secondary Outcome Measures

Name	Time	Method
ROX index evaluation for risk of intubation	48 hours	The Respiratory Rate-Oxygenation Index can predict the risk of intubation Higher score means lower risk
LUSS/ROX index ratio evaluation for risk of intubation	48 hours	LUSS/ROX index ratio can predict the risk of intubation

Trial Locations

Locations (2)

Prof. Dr. Cemil Tascıoglu City Hospital; 🇹🇷 İstanbul, Şişli, Turkey

Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization; 🇹🇷 Istanbul, Şişli, Turkey