Relationship between NT-proBNP and cognitive function among patients with aneurysmal subarachnoid hemorrhage (COGNI-SAH): a prospective observational study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 170
- 试验地点
- 1
- 主要终点
- incidence of cognitive dysfunction at hospital discharge among patients with altered NT-proBNP levels after aSAH
研究概览
简要总结
Cognitive dysfunction has been reported to be as high as 73% at 3 months after aSAH in a small-sampled study. Autonomic dysfunction is a common complication during the acute phase of aneurysmal rupture. Various heart rate variability (HRV) parameters have been proposed to predict cognition in these patients. NT-proBNP is an important myocardial injury marker, similar to the brain natriuretic peptide (BNP). HRV correlates with NT-proBNP levels in patients with acute myocardial ischemia and cardiac failure. The acute surge in BNP after aSAH may predict sodium disturbances, vasospasm and DCI. BNP also influences delirium in cardiac surgical patients and predicts vascular death following non-cardiac surgeries. The role of NT-proBNP in predicting cognitive and autonomic dysfunction is yet to be studied among patients with aSAH.
The trend of change in NT-proBNP levels after aSAH may correlate with the HRV metrics from baseline till day 7-10 of ictus, which coincides with the time of hospital discharge and can predict cognitive function at discharge and the quality of life at 3 months.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 80.00 Year(s)（—）
- 性别
- All
入选标准
- •All patients more than 18 years of age admitted to NIMHANS for surgical clipping or coiling of aneurysm 2) Presentation within 72 hours of ictus 3) WFNS 1 and any MF grade.
排除标准
- •Presentation beyond 72 hours of ictus 3) WFNS 2 or more.
结局指标
主要结局
incidence of cognitive dysfunction at hospital discharge among patients with altered NT-proBNP levels after aSAH
时间窗: On admission, 24 hours after surgery, hospital discharge, 3 months after hospital discharge
次要结局
- 3.Effect of NT-proBNP on sodium disturbances, duration of hospital stay, mortality, functional outcome and quality of life at 3 months(On admission, 24 hours after surgery, hospital discharge, 3 months after hospital discharge)
- 2.Correlation of the trend of change in HRV metrics with NT-proBNP, cognition and quality of life at and after 3 months of hospital discharge(On admission, 24 hours after surgery, hospital discharge, 3 months after hospital discharge)
- 1.Correlation of NT-proBNP with baseline clinical characteristics (cerebral edema, WFNS grade, MF grade, ECG abnormalities)(On admission)