The Role of the Neuropsychological Evaluation for Early Diagnosis of Progressive Supranuclear Palsy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 112
- 主要终点
- MoCA
研究概览
简要总结
The aim of this study is to better understand the nature of the cognitive decline in Progressive Supranuclear Palsy, the time of its development and the relation with the other cardinal features of the disease.
详细描述
Progressive Supranuclear Palsy (PSP) is a neurodegenerative disease characterized by vertical supranuclear gaze palsy, early balance dysfunction and falls. Tau-protein aggregation, mainly in the brainstem, is the disease hallmark. Because of the similarities with Parkinson's disease (PD), the diagnosis is made approximately 4 years after the symptoms onset. Cognitive deficits are a leading feature of PSP and they actually represent one of the four functional core domains in the revised diagnostic criteria. The aim of this study is to better understand the nature of this cognitive decline, the time of its development and the relation with the other cardinal features of the disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 接受健康志愿者
- 否
入选标准
- •Patients fulfilling the criteria for idiopathic PD
- •Patients fulfilling the criteria for PSP
排除标准
- •Any other neurodegenerative disorders or medical conditions different from PD / PSP
结局指标
主要结局
MoCA
时间窗: 1 year
Montreal Cognitive Assessment
RAVLT
时间窗: 1 year
Rey Auditory Verbal Learning Test
MMSE
时间窗: 1 year
Mini-Mental State Examination
WCST
时间窗: 1 year
Wisconsin Card Sorting Test
FAB
时间窗: 1 year
Frontal Assessment Battery
ST
时间窗: 1 year
Stroop Test
TMT-A and B
时间窗: 1 year
Trail Making Test Parts A \& B
VFT
时间窗: 1 year
Verbal fluency Test
ROCF copy and delayed recall
时间窗: 1 year
Rey-Osterrieth complex figure test copy and delayed recall
次要结局
- TUG(1 year)
- 6MWT(1 year)
- BBS(1 year)