The Role of the Neuropsychological Evaluation for Early Diagnosis of Progressive Supranuclear Palsy
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Progressive Supranuclear Palsy
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
- Enrollment
- 112
- Primary Endpoint
- MoCA
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
The aim of this study is to better understand the nature of the cognitive decline in Progressive Supranuclear Palsy, the time of its development and the relation with the other cardinal features of the disease.
Detailed Description
Progressive Supranuclear Palsy (PSP) is a neurodegenerative disease characterized by vertical supranuclear gaze palsy, early balance dysfunction and falls. Tau-protein aggregation, mainly in the brainstem, is the disease hallmark. Because of the similarities with Parkinson's disease (PD), the diagnosis is made approximately 4 years after the symptoms onset. Cognitive deficits are a leading feature of PSP and they actually represent one of the four functional core domains in the revised diagnostic criteria. The aim of this study is to better understand the nature of this cognitive decline, the time of its development and the relation with the other cardinal features of the disease.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients fulfilling the criteria for idiopathic PD
- •Patients fulfilling the criteria for PSP
Exclusion Criteria
- •Any other neurodegenerative disorders or medical conditions different from PD / PSP
Outcomes
Primary Outcomes
MoCA
Time Frame: 1 year
Montreal Cognitive Assessment
RAVLT
Time Frame: 1 year
Rey Auditory Verbal Learning Test
MMSE
Time Frame: 1 year
Mini-Mental State Examination
WCST
Time Frame: 1 year
Wisconsin Card Sorting Test
FAB
Time Frame: 1 year
Frontal Assessment Battery
ST
Time Frame: 1 year
Stroop Test
TMT-A and B
Time Frame: 1 year
Trail Making Test Parts A \& B
VFT
Time Frame: 1 year
Verbal fluency Test
ROCF copy and delayed recall
Time Frame: 1 year
Rey-Osterrieth complex figure test copy and delayed recall
Secondary Outcomes
- TUG(1 year)
- 6MWT(1 year)
- BBS(1 year)